Methylglucoside | 25360-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methylglucoside
• 英文别名: (3S,5R)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol
• CAS: 25360-07-0
• 化学式: C₇H₁₄O₆
• 分子量: 194.18
• InChiKey: HOVAGTYPODGVJG-UVSYOFPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  葡萄糖 、 甲醇 反应 0.03h， 生成 Methylglucoside
  参考文献：
  名称：

  Process for preparing alkylglycosides

  摘要：

  本发明涉及一种从单体糖苷、寡糖或多糖和醇制备烷基多聚糖的方法，根据通用方案（Glyc-O）zH+R1—OH→（Glyc-O）z′R1，其中z≧1，z′≦z，优选从1到10，（Glyc-O）-是糖苷基团，R1是含有多重键和/或杂原子的碳氢基团，其包括在超临界条件下进行反应，以醇为溶剂和反应物，优选在至少比临界参数高5％的压力和温度下进行反应。

  公开号：

  US20050261484A1

文献信息

• [EN] β-1,6-GLUCAN THERAPEUTIC ANTIBODY CONJUGATES<br/>[FR] CONJUGUÉS D'ANTICORPS THÉRAPEUTIQUE DE β-1,6-GLUCANE
  申请人：INNATE BIOTHERAPEUTICS LLC

  公开号：WO2018106645A1

  公开（公告）日：2018-06-14

  The present invention encompasses embodiments in which a therapeutic antibody is conjugated to β-1,6-glucan oligomers. Thus, the present invention includes, among other things, compositions including a therapeutic antibody conjugated to one or more β-1-,6-glucan oligomers. The present invention further includes, among other things, methods of making and/or using such β-1,6-glucan conjugates. In certain embodiments, a β-1,6-glucan conjugate of the present invention is useful as a therapeutic or in a method of therapy.

  本发明涵盖了将治疗性抗体与β-1,6-葡聚糖寡聚体结合的实施方式。因此，本发明包括包含治疗性抗体与一个或多个β-1,6-葡聚糖寡聚体结合的组合物，以及制备和/或使用这种β-1,6-葡聚糖结合物的方法。在某些实施方式中，本发明的β-1,6-葡聚糖结合物可用作治疗性药物或治疗方法。
• Method for functionalizing materials and devices comprising such materials
  申请人：Yan Mingdi

  公开号：US20100028559A1

  公开（公告）日：2010-02-04

  Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, device surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide. In some embodiments, graphite is functionalized with perhalophenylazide to produce a functionalized graphene sheet. In other embodiments, graphene sheets are covalently attached to functionalized substrates.

  本发明公开了包括功能化材料的装置以及制备和使用这种装置的方法的实施例。示例装置包括眼科装置、纳米颗粒、石英晶体微天平、微阵列和纳米复合材料。在特定的实施例中，装置表面使用单体和/或聚合物进行修饰，通常是碳水化合物单体和/或聚合物。本发明还公开了制备和使用这种装置的方法的实施例。使用功能化的过卤苯基偶氮苯酰胺共价键结合单体和/或聚合物到表面上。在某些实施例中，装置表面被功能化为过卤苯基偶氮苯酰胺。然后使用过卤苯基偶氮苯酰胺将一个或多个单体和/或聚合物共价键结合到装置表面上。在其他实施例中，单体和/或聚合物使用功能化的过卤苯基偶氮苯酰胺衍生。然后使用过卤苯基偶氮苯酰胺将衍生的单体和/或聚合物共价键结合到装置表面上。在某些实施例中，石墨使用过卤苯基偶氮苯酰胺进行功能化，以产生功能化石墨烯薄片。在其他实施例中，石墨烯薄片与功能化基底共价键结合。
• TARGETING LIPIDS
  申请人：Arbutus Biopharma Corporation

  公开号：EP3156077A1

  公开（公告）日：2017-04-19

  The present invention provides targeting lipids of structure (Cl) L100 - linker - L101, where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or -CH2CH2(OCH2CH2)pO(CH2)qCH2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo.

  本发明提供了结构为（Cl）L100-连接体-L101的靶向脂质，其中L100为脂质、亲脂质、烷基、烯基或炔基，L101为配体或-CH2CH2(OCH2CH2)pO(CH2)qCH2-配体，p为1-1000，q为1-20。此外，本发明还提供了向细胞输送治疗剂的组合物和方法。其中特别包括新型脂质和核酸-脂质颗粒，它们能有效地封装核酸，并在体内将封装的核酸有效地递送到细胞中。
• US8679859B2
  申请人：——

  公开号：US8679859B2

  公开（公告）日：2014-03-25
• [EN] AUTOPHAGY INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS FOR THE USE THEREOF IN THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS INHIBITEURS DE L'AUTOPHAGIE, COMPOSITIONS ET PROCÉDÉS POUR L'UTILISATION DE CELLES-CI DANS LE TRAITEMENT DU CANCER
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2011017809A1

  公开（公告）日：2011-02-17

  Compositions comprising compounds of Formula IA and IB and cancer therapeutics are provided. Uses of and methods of using such compounds and compositions are provided for the modulation of autophagy. In particular, compounds and compositions may be for use in early stage autophagy inhibition and in the treatment of cancer. Furthermore, the treatment may be in combination with a cancer therapeutics agent.