2-Oxetanone, 4-(8Z)-8-heptadecenylidene-3-(7Z)-7-hexadecenyl- | 56000-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-Oxetanone, 4-(8Z)-8-heptadecenylidene-3-(7Z)-7-hexadecenyl-
• 英文别名: 4-heptadec-8-enylidene-3-hexadec-7-enyloxetan-2-one
• CAS: 56000-16-9
• 化学式: C₃₆H₆₄O₂
• 分子量: 528.9
• InChiKey: YOZPNLKELYIIKS-UHFFFAOYSA-N

物化性质

• 沸点：
  625.8±24.0 °C(Predicted)
• 密度：
  0.913±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  15.2
• 重原子数：
  38
• 可旋转键数：
  28
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL CERAMIDE DERIVATIVES HAVING AGONISTIC EFFECTS ON EPIDERMAL CANNABINOID RECEPTORS, AND PHARMACEUTICAL OR COSMETIC COMPOSITION CONTAINING SAME
  申请人：NEOPHARM CO., LTD.

  公开号：US20160272578A1

  公开（公告）日：2016-09-22

  The present invention relates to a novel pseudoceramide derivative, a pharmaceutically acceptable salt thereof or a solvate thereof, and a pharmaceutical or cosmetic composition containing the same as an active ingredient. The novel pseudoceramide derivative of the present invention is expected to be very useful for treating or preventing skin diseases by activating cannabinoid receptors. In addition, the novel pseudoceramide derivative, the pharmaceutically acceptable salt thereof or the solvate thereof, of the present invention, has a simple synthesis process compared with a known cannabinoid receptor antagonist so as to reduce processing time and curtail material costs, and thus is economical, and has advantages such as easy emulsification during the formulation of cosmetic products or medical supplies.

  本发明涉及一种新型的伪神经酰胺衍生物，其药学上可接受的盐或其溶剂，并且一种含有该衍生物作为活性成分的制药或化妆品组合物。本发明的新型伪神经酰胺衍生物通过激活大麻素受体，预计非常有用于治疗或预防皮肤疾病。此外，本发明的新型伪神经酰胺衍生物、其药学上可接受的盐或其溶剂与已知的大麻素受体拮抗剂相比，具有简单的合成过程，从而减少处理时间和材料成本，因此经济实惠，并具有易于在化妆品或医疗用品的制剂过程中乳化的优点。
• COMPOSITIONS FOR IMPARTING DESIRED PROPERTIES TO MATERIALS
  申请人：HERCULES INCORPORATED

  公开号：EP1299488A2

  公开（公告）日：2003-04-09
• WATER REPELLENT COMBINATIONS
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP3347421A1

  公开（公告）日：2018-07-18
• Paper Sizing Composition
  申请人：Ehrhardt Susan M.

  公开号：US20110146926A1

  公开（公告）日：2011-06-23

  A stable paper sizing composition comprising a dispersion of ketene dimer and a pH adjusted vinylamine containing polymer is disclosed. The method of preparing the stable sizing composition and the method of using the stable sizing composition is also disclosed.
• US7317053B1
  申请人：——

  公开号：US7317053B1

  公开（公告）日：2008-01-08