9-Arabinofuranosyladenine | 2006-02-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 9-Arabinofuranosyladenine
• 英文别名: (3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 2006-02-2
• 化学式: C₁₀H₁₃N₅O₄
• 分子量: 267.24
• InChiKey: OIRDTQYFTABQOQ-KBNQYOMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE DE MOLÉCULES PHOSPHORYLÉES
  申请人：UNIV CALIFORNIA

  公开号：WO2019195494A1

  公开（公告）日：2019-10-10

  The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

  这项发明提供了合成磷酸化有机化合物的组合物和方法，包括核苷三磷酸。
• Antisense oligonucleotide modulation of human serine/threonine protein phosphatase gene expression
  申请人：——

  公开号：US20020082415A1

  公开（公告）日：2002-06-27

  Oligonucleotides are provided which are targeted to nucleic acids encoding human serine/threonine protein phosphatases and which are capable of inhibiting protein phosphatase expression. Methods of inhibiting the expression of human protein serine/threonine phosphatases using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal conditions, including cancer, using oligonucleotides of the invention.

  提供了针对编码人类丝氨酸/苏氨酸蛋白磷酸酶的核酸寡核苷酸，并且这些寡核苷酸能够抑制蛋白磷酸酶的表达。本发明还提供了使用该发明的寡核苷酸抑制人类蛋白质丝氨酸/苏氨酸磷酸酶表达的方法。本发明还包括使用该发明的寡核苷酸预防或抑制细胞的高增殖以及治疗异常情况（包括癌症）的方法。
• 9-Substituted adenine derivatives as prodrug regulators of cell and tissue function
  申请人：——

  公开号：US20040053825A1

  公开（公告）日：2004-03-18

  The present invention relates to 9-substituted adenine derivatives that inhibit adenylyl cyclase in cells but have little or no effect on isolated adenylyl cyclase. The derivatives are useful as prodrugs for inhibiting adenylyl cyclase and lowering 3′:5′-cAMP in cells, thereby inhibiting adenylyl cyclase dependent effects within cells.

  本发明涉及9-取代腺嘌呤衍生物，它们能抑制细胞中的腺苷酸环化酶，但对单独的腺苷酸环化酶几乎没有影响。这些衍生物可用作前药，用于抑制细胞中的腺苷酸环化酶并降低细胞中的3′：5′-cAMP，从而抑制细胞内腺苷酸环化酶依赖性效应。
• Antiviral oligonucleotides having a conserved G4 core sequence
  申请人：Hanecak C. Ronnie

  公开号：US20070015723A1

  公开（公告）日：2007-01-18

  Modified oligonucleotides having a conserved G 4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus or phospholipase A 2 or to modulate the telomere length of a chromosome are provided. G 4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A 2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.

  提供具有保守的G4序列和足够数量的侧翼核苷酸的修饰寡核苷酸，可以显著抑制病毒或磷脂酶A2的活性或调节染色体端粒长度。还提供了G4四链体寡核苷酸结构。还提供了预防病毒相关疾病和与磷脂酶A2水平升高相关的疾病的诊断和治疗方法。还提供了调节染色体端粒长度的方法；调节染色体端粒长度被认为在细胞老化过程和恶性细胞生长的控制中起作用。
• Antiviral Oligonucleotides Having a Conserved G4 Core Sequence
  申请人：Hanecak Ronnie C.

  公开号：US20110124715A1

  公开（公告）日：2011-05-26

  Modified oligonucleotides having a conserved G 4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus are provided. G 4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases are also provided.

  提供了具有保守的G4序列和足够数量的侧翼核苷酸以显著抑制病毒活性的修饰寡核苷酸。还提供了G4四联体寡核苷酸结构。此外，还提供了针对病毒相关疾病的预防、诊断和治疗方法。