N⁶-methyl-N⁶-nitroso-adenosine | 41286-73-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N⁶-methyl-N⁶-nitroso-adenosine
• 英文别名: N-Methyl-N-nitrosoadenosine；N-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]-N-methylnitrous amide
• CAS: 41286-73-1
• 化学式: C₁₁H₁₄N₆O₅
• 分子量: 310.269
• InChiKey: AGGQXACVVHIHNR-IOSLPCCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• DETECTION OF NUCLEIC ACID MODIFICATIONS BY USING CHEMICAL DEAMINATION
  申请人：Helm, Mark

  公开号：EP3725895A1

  公开（公告）日：2020-10-21

  The present invention relates to methods for detecting the position of a nucleotide modification, selected from the group consisting of N6-methyladenosine (m6A) and N4-methylcytidine (m4C), in one or more RNA species. Said methods are based on a deamination of the RNA followed by reverse transcription and sequencing of the resulting cDNAs.

  本发明涉及检测一种或多种 RNA 中核苷酸修饰位置的方法，这些核苷酸修饰选自 N6-甲基腺苷（m6A）和 N4-甲基胞苷（m4C）组成的组。所述方法基于对 RNA 进行脱氨基处理，然后对得到的 cDNA 进行反转录和测序。
• [EN] DETECTION OF NUCLEIC ACID MODIFICATIONS BY USING CHEMICAL DEAMINATION<br/>[FR] DÉTECTION DE MODIFICATIONS D'ACIDE NUCLÉIQUE AU MOYEN D'UNE DÉSAMINATION CHIMIQUE
  申请人：HELM MARK

  公开号：WO2020212512A1

  公开（公告）日：2020-10-22

  The present invention relates to methods for detecting the position of a nucleotide modification, selected from the group consisting of N 6 -methyladenosine (m6A) and N 4 -methylcytidine (m4C), in one or more RNA species. Said methods are based on a deamination of the RNA followed by reverse transcription and sequencing of the resulting cDNAs.