申请人:Timmer T. Richard
公开号:US20070122444A1
公开(公告)日:2007-05-31
The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.
本发明涉及用于治疗由炎症反应引起的病理生理条件的方法、化合物和组合物,其针对的是抑制或阻断糖基化蛋白诱导的内皮细胞信号相关炎症反应的化合物。本发明还涉及抑制平滑肌增殖的化合物,例如通过调节HSPGs(如Perlecan)来实现。本发明进一步涉及使用化合物来治疗由平滑肌增殖所特征的血管闭塞性疾病,例如再狭窄和动脉粥样硬化。本发明还涉及医疗器械,例如支架,其包括本发明的化合物或组合物在医疗器械上或内部安置。