6-Amino-6-deoxy-d-mannose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-Amino-6-deoxy-d-mannose
• 英文别名: (2S,3S,4R,5R)-6-amino-2,3,4,5-tetrahydroxyhexanal
• 化学式: C₆H₁₃NO₅
• 分子量: 179.17
• InChiKey: HDXVFGYNQCBFKD-KVTDHHQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  124
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• METHOD FOR IMAGING CELL USING FLUORESCENCE-LABELED SUGAR DERIVATIVE HAVING COUMARIN DERIVATIVE BOUND THERETO, AND IMAGING AGENT
  申请人：Hirosaki University

  公开号：US20150369797A1

  公开（公告）日：2015-12-24

  The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule.

  本发明旨在提供一种发出蓝色荧光颜色的糖衍生物，可用于细胞或细胞内分子的成像，以及使用该衍生物成像细胞的方法。此外，本发明旨在提供一种通过成像高精度检测癌细胞的方法，以及用于该方法的成像剂。本发明提供一种含有3-羧基-6,8-二氟-7-羟基香豆素或3-羧甲基-6,8-二氟-7-羟基-4-甲基香豆素作为其分子中的荧光分子基团的荧光标记糖衍生物，以及使用该衍生物的细胞成像剂和成像方法。此外，本发明提供一种使用具有上述荧光分子基团的L-葡萄糖衍生物的成像剂和成像方法，用于癌细胞。
• MEDICAL POLYMERS AND USE THEREOF
  申请人：Keio University

  公开号：EP1439199A1

  公开（公告）日：2004-07-21

  The present invention provides a polyethylene glycol derivative having sugar residue-containing side chains and carboxyl group-containing side chains, and a method of preparing the same. The present invention also provides a carrier for drug delivery systems and a carrier for gene transfer, both comprising the polyethylene glycol derivative.

  本发明提供了一种具有含糖残基侧链和含羧基侧链的聚乙二醇衍生物及其制备方法。本发明还提供了一种用于给药系统的载体和一种用于基因转移的载体，两者都包含聚乙二醇衍生物。
• Method for imaging cell using fluorescence-labeled sugar derivative having coumarin derivative bound thereto, and imaging agent
  申请人：HIROSAKI UNIVERSITY

  公开号：US10288604B2

  公开（公告）日：2019-05-14

  The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule.

  本发明的目的是提供一种能发出蓝色荧光、可用于细胞或细胞内分子成像的糖衍生物，以及使用该衍生物进行细胞成像的方法。此外，本发明的目的还在于提供一种通过成像高精度检测癌细胞的方法，以及用于该方法的成像剂。本发明提供了一种荧光标记的糖衍生物，其分子中的荧光分子基团为3-羧基-6,8-二氟-7-羟基香豆素或3-羧甲基-6,8-二氟-7-羟基-4-甲基香豆素，以及一种细胞成像剂和一种使用该衍生物的成像方法。此外，本发明还提供了一种使用分子中含有上述荧光分子基团的 L-葡萄糖衍生物的癌细胞成像剂和成像方法。
• Medical polymers and uses thereof
  申请人：——

  公开号：US20040097659A1

  公开（公告）日：2004-05-20

  The present invention provides a polyethylene glycol derivative having sugar residue-containing side chains and carboxyl group-containing side chains, and a method of preparing the same. The present invention also provides a carrier for drug delivery systems and a carrier for gene transfer, both comprising the polyethylene glycol derivative.

  本发明提供了一种具有含糖残基侧链和含羧基侧链的聚乙二醇衍生物及其制备方法。 本发明还提供了一种用于给药系统的载体和一种用于基因转移的载体，两者都包含聚乙二醇衍生物。
• SOLID CATALYSTS FOR CONTINUOUS INTERCONVERSION OF EPIMERIC ALDOSES AND ALDOSE ANALOGS
  申请人：AlliedSignal Inc.

  公开号：EP0400064A1

  公开（公告）日：1990-12-05