(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,5S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,5S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
• 化学式: C₃₇H₆₇NO₁₃
• 分子量: 733.9
• InChiKey: ULGZDMOVFRHVEP-LRUVNAJRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  51
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  194
• 氢给体数：
  5
• 氢受体数：
  14

文献信息

• COMBINATION THERAPY TO TREAT MYCOBACTERIUM DISEASES
  申请人：Locher Christopher Phillip

  公开号：US20140045791A1

  公开（公告）日：2014-02-13

  The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.

  本发明涉及式(I)化合物或其药学上可接受的盐，其中X和R的定义如本文所述。式(I)化合物可用作抑制DNA旋转酶和/或拓扑异构酶IV的抑制剂，用于治疗细菌感染。式(I)化合物具有广泛的抗菌活性和优越的毒理学特性，或者是具有该活性的前药。
• Aqueous Compositions
  申请人：SYMRISE AG

  公开号：US20140135349A1

  公开（公告）日：2014-05-15

  Suggested is a non-therapeutic aqueous composition for topical application, comprising (a) at least one solid active agent having at 20° C. a solubility in water (20° dH) of less than 5 g/L; (b) at least one 1,2-alkandiol having 4 to 12 carbon atoms; and (c) at least one aliphatic alcohol having 2 to 4 carbon atoms.
• Ginger Extract for the Protection of Stem Cells
  申请人：Symrise AG

  公开号：US20140242020A1

  公开（公告）日：2014-08-28

  Suggested is a ginger extract, comprising (a) 25 to 30% b.w. [6]-gingerol (b) 5 to 10% b.w. [8]-gingerol (c) 5 to 10% b.w. [10]-gingerol (d) 1.5 to 4% b.w. [6]-shogaol (e) 0.3 to 1.3% b.w. [8]-shogaol; (f) 0.03 to 1% b.w. [10]-shogaol; (g) 0.01 to 1% b.w. zingerone, on condition that the amount of gingerols sums up to 35 to 50% b.w. and the amount of shogaols sums up to 1.5 to 6% b.w.
• ACTIVE MIXTURES
  申请人：Symrise AG

  公开号：US20160206571A1

  公开（公告）日：2016-07-21

  Suggested is an active mixture comprising (a) 1,2-hexanediol and (b) 1,2-octanediol.
• US9125936B2
  申请人：——

  公开号：US9125936B2

  公开（公告）日：2015-09-08