(S)-6-Hydroxymethyl-tetrahydro-pyran-2,3,4,5-tetraol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-6-Hydroxymethyl-tetrahydro-pyran-2,3,4,5-tetraol
• 英文别名: (2S)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
• 化学式: C₆H₁₂O₆
• 分子量: 180.16
• InChiKey: WQZGKKKJIJFFOK-IHVYINHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20140235575A1

  公开（公告）日：2014-08-21

  The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

  本发明提供了一种一锅多酶法，用于从简单糖起始材料制备UDP糖。该发明还提供了一种一锅多酶法，用于从简单糖起始材料制备寡糖。
• [EN] NANOPARTICLES AND THEIR USE IN CANCER THERAPY<br/>[FR] NANOPARTICULES ET LEUR UTILISATION DANS LA THÉRAPIE DU CANCER
  申请人：MIDATECH LTD

  公开号：WO2016102613A1

  公开（公告）日：2016-06-30

  The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.

  本发明提供了一种纳米颗粒，包括一个包含金属的核心；以及一个包含多个配体的辐状结构，这些配体中至少包括一种包含乙二醇部分和胺基的第一种配体，以及至少一种包含碳水化合物基团的第二种配体，用于治疗哺乳动物主体中的癌症，特别是皮肤癌。还公开了通过单独或与放射疗法结合使用这些纳米颗粒的治疗方法。
• DRUG DELIVERY CONJUGATES OF TERTIARY AMINE CONTAINING DRUGS
  申请人：ENDOCYTE, INC.

  公开号：US20180125992A1

  公开（公告）日：2018-05-10

  The present disclosure relates to conjugates of tertiary amine containing drugs. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making, and methods of using the same.

  本公开涉及含有三级胺的药物的共轭物。本公开还涉及所述共轭物的制药组合物、制备方法和使用方法。
• Glycated CD59 peptides, their preparation, and uses thereof
  申请人：President and Fellows of Harvard College

  公开号：US11161910B2

  公开（公告）日：2021-11-02

  The present invention provides glycated Amadori products of the CD59 peptide and fragments thereof to be used as tools and among methods for the diagnosis and prognosis of pre-diabetes and diabetes. Certain aspects of the invention include glycated Amadori products of CD59 and fragments thereof to be used for the generation of antibodies and antibody fragments. Still other aspects of the invention include methodologies for the preparation of glycated Amadori products of CD59, fragments thereof, the inventive antibodies, and antibody fragments.

  本发明提供了CD59肽的糖化Amadori产物及其片段，可用作诊断糖尿病前期和糖尿病的工具和方法。本发明的某些方面包括用于生成抗体和抗体片段的 CD59 的糖化阿莫多利产物及其片段。本发明的其他方面还包括制备CD59的糖化阿莫多利产物、其片段、本发明抗体和抗体片段的方法。
• DUAL DISULFIDE DRUG CONJUGATES
  申请人：ENDOCYTE, INC.

  公开号：US20180110871A1

  公开（公告）日：2018-04-26

  The invention described herein pertains to dual disulfide drug conjugates. In particular, the invention described herein pertains to dual disulfide drug conjugates that target the folate receptor for delivery of conjugated drugs to a mammalian recipient. Also described are methods of making and using dual disulfide drug conjugates.