5-(Methylthio)-2-[(methylthio)methyl]-2-pentenal | 59902-01-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(Methylthio)-2-[(methylthio)methyl]-2-pentenal
• 英文别名: (E)-5-methylsulfanyl-2-(methylsulfanylmethyl)pent-2-enal
• CAS: 59902-01-1
• 化学式: C₈H₁₄OS₂
• 分子量: 190.3
• InChiKey: VVZWQNGEMWJSTM-XBXARRHUSA-N

物化性质

• 沸点：
  318.2±42.0 °C(Predicted)
• 密度：
  1.061±0.06 g/cm3 (20 ºC 760 Torr)
• LogP：
  2.19
• 溶解度：
  slightly soluble in water
• 折光率：
  1.557-1.567
• 保留指数：
  1567

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  3

制备方法与用途

毒性：GRAS（FEMA）。

使用限量：

• 肉制品、汤品、调味品、腌制品及调味香料：0.2 mg/kg。

化学性质：

• 微溶于水，天然存在于番茄汁中。

用途：

• 食品用香料。

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Method for producing 3-methylthiopropanal
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20040063650A1

  公开（公告）日：2004-04-01

  A 3-methylthiopropanal is produced by a method comprising the step of supplying an acrolein and a methyl mercaptan together or sequentially with an acidic compound and a basic compound into a reaction system to react the acrolein with the methyl mercaptan, wherein the basic compound is used in an amount of about 0.3 mol or less per mol of the acidic compound. In accordance with the present invention, a 3-methylthiopropanal with high quality is produced while suppressing the production of by-products having high boiling points.

  一种生产3-甲基硫代丙醛的方法，包括将丙烯醛和甲硫醇与酸性化合物和碱性化合物一起或依次供应到反应系统中，以使丙烯醛与甲硫醇发生反应，其中碱性化合物的用量为每摩尔酸性化合物约0.3摩尔或更少。根据本发明，在抑制高沸点副产物的产生的同时，生产高质量的3-甲基硫代丙醛。
• Compounds useful as modulators of TRPM8
  申请人：Senomyx, Inc.

  公开号：US10392371B2

  公开（公告）日：2019-08-27

  Provided herein are compounds which are useful as cooling sensation compounds.

  本文提供的化合物可用作冷感化合物。
• Antiperspirant and deodorant compositions
  申请人：The Procter & Gamble Company

  公开号：US10568825B2

  公开（公告）日：2020-02-25

  The present application relates to antiperspirant compositions comprising perfumes and sulfur-based perfume raw materials, and methods for making and using the antiperspirant compositions.

  本申请涉及包含香水和硫基香水原料的止汗剂组合物，以及制造和使用止汗剂组合物的方法。