(2R,5R)-5-acetamido-4-hydroxy-2-methoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,5R)-5-acetamido-4-hydroxy-2-methoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• 化学式: C₁₂H₂₁NO₉
• 分子量: 323.3
• InChiKey: NJRVVFURCKKXOD-XXFIRWGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Sialidase inhibitors and preparation thereof
  申请人：The Regents of the University of California

  公开号：US11325936B2

  公开（公告）日：2022-05-10

  New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.

  本发明公开了可用作硅糖苷酶抑制剂的新型 2-脱氧-2,3-脱氢-硅酸和 2,7-脱水-硅酸，以及制备它们的酶法。这些方法包括形成一种反应混合物，其中包括糖苷受体、硅烷基酸供体和硅烷基转移酶；将反应混合物保持在足以形成硅烷基苷的条件下；以及将硅烷基苷与肺炎链球菌硅烷基酶接触以形成硅烷基酸产物。此外，还公开了抑制硅烷基糖苷酶以及治疗癌症和传染性疾病的方法。
• NOVEL COMPOUNDS HAVING ANTIVIRAL ACTIVITY
  申请人：NISSIN FOOD PRODUCTS CO., LTD.

  公开号：EP0957107B1

  公开（公告）日：2004-07-21
• 2,3-FLUORINATED GLYCOSIDES AS NEURAMINIDASE INHIBITORS AND THEIR USE AS ANTI-VIRALS
  申请人：The University of British Columbia

  公开号：EP2454268B1

  公开（公告）日：2014-09-10
• Neuraminidase Inhibitor Compounds, Compositions and Methods for the Use Thereof in Anti-Viral Treatments
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20150216838A1

  公开（公告）日：2015-08-06

  Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.
• SIALIDASE INHIBITORS AND PREPARATION THEREOF
  申请人：The Regents of the University of California

  公开号：US20200190130A1

  公开（公告）日：2020-06-18

  New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.