(3aR,5S)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5S)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol
• 化学式: C₁₂H₂₀O₆
• 分子量: 260.28
• InChiKey: KEJGAYKWRDILTF-DRAUJQIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• OLIGNUCLEOTIDES COMPRISING A LIGAND TETHERED TO A MODIFIED OR NON-NATURAL NUCLEOBASE
  申请人：MANOHARAN Muthiah

  公开号：US20090312531A1

  公开（公告）日：2009-12-17

  One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage.

  本发明的一个方面涉及一种双链寡核苷酸，其中至少有一种配体被系着到改变或非自然的核碱基上。在某些实施例中，非自然的核碱基是二氟基甲苯基、硝基吡咯基或硝基咪唑基。在某些实施例中，配体是类固醇或芳香族化合物。在某些实施例中，只有双链寡核苷酸中的两条寡核苷酸链中的一条包含系着到改变或非自然核碱基上的配体。在某些实施例中，双链寡核苷酸中的两条寡核苷酸链都独立地包含系着到改变或非自然核碱基上的配体。在某些实施例中，寡核苷酸链包含至少一个改变的糖基团。本发明的另一个方面涉及一种单链寡核苷酸，其中至少有一种配体被系着到改变或非自然的核碱基上。在某些实施例中，非自然的核碱基是二氟基甲苯基、硝基吡咯基或硝基咪唑基。在某些实施例中，配体是类固醇或芳香族化合物。在某些实施例中，自然存在于核苷中的核糖糖基团被替换为六碳糖、多环杂环烷基环或环己烯基团。在某些实施例中，寡核苷酸中至少有一个磷酸酯键被磷酸硫酯键替换。
• ANTICOAGULANT COMPOUNDS
  申请人：Petitou Maurice

  公开号：US20100081708A1

  公开（公告）日：2010-04-01

  The present invention is concerned with anticoagulants (i.e. substances that stop blood from clotting). More specifically, the present invention is concerned with orally available antithrombic oligosaccharides.

  本发明涉及抗凝剂（即阻止血液凝结的物质）。更具体地说，本发明涉及口服可用的抗血栓寡糖。
• SYNTHETIC HEPARIN TRISACCHARIDES
  申请人：SEIFERT Joachim

  公开号：US20120208993A1

  公开（公告）日：2012-08-16

  Preparation and use of synthetic trisaccharides useful for the preparation of synthetic heparinoids.

  合成三糖的制备和使用，适用于合成肝素类化合物的制备。
• SYNTHETIC HEPARIN PENTASACCHARIDES
  申请人：ALCHEMIA LIMITED

  公开号：US20150005485A1

  公开（公告）日：2015-01-01

  Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides useful for the preparation of synthetic heparinoids.

  合成单糖，双糖，三糖，四糖和五糖的制备和使用，用于制备合成肝素类化合物。
• METHODE FOR PRODUCING F-LABELLED COMPOUND AND HIGH MOLECULAR COMPOUND TO BE USED IN THE METHOD
  申请人：Tokyo Institute of Technology

  公开号：EP2537854A1

  公开（公告）日：2012-12-26

  The present invention aims at solving the problems of conventional methods for producing an 18F-labeled compound, that is, the problem of purification of a compound in a liquid phase synthesis method and the problem of an insufficient yield due to the reduction of reactivity in a solid phase synthesis method. There is provided a method for producing an 18F-labeled compound including: allowing a high molecular compound containing a residue of a precursor compound to be labeled and a residue of a phase transfer catalyst in the molecule thereof to react with 18F-; and removing the 18F-labeled compound from the high molecular compound.

  本发明旨在解决生产 18F 标记化合物的传统方法中存在的问题，即液相合成方法中的化合物纯化问题和固相合成方法中由于反应活性降低导致产率不足的问题。本发明提供了一种生产 18F 标记化合物的方法，包括：让含有待标记前体化合物残留物的高分子化合物及其分子中的相转移催化剂残留物与 18F- 反应；以及从高分子化合物中去除 18F 标记化合物。