1-isopropylamino-3-(6-methoxy-pyridazin-3-yloxy)-propan-2-ol | 54126-98-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-isopropylamino-3-(6-methoxy-pyridazin-3-yloxy)-propan-2-ol
• 英文别名: 1-[(6-Methoxypyridazin-3-yl)oxy]-3-[(propan-2-yl)amino]propan-2-ol；1-(6-methoxypyridazin-3-yl)oxy-3-(propan-2-ylamino)propan-2-ol
• CAS: 54126-98-6
• 化学式: C₁₁H₁₉N₃O₃
• 分子量: 241.29
• InChiKey: ADFAWZUDXRFTFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  76.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• TARGETED DRUG RESCUE WITH NOVEL COMPOSITIONS, COMBINATIONS, AND METHODS THEREOF
  申请人：Exciva GmbH

  公开号：EP3618819A1

  公开（公告）日：2020-03-11
• US4115575A
  申请人：——

  公开号：US4115575A

  公开（公告）日：1978-09-19
• US4195090A
  申请人：——

  公开号：US4195090A

  公开（公告）日：1980-03-25
• US4410530A
  申请人：——

  公开号：US4410530A

  公开（公告）日：1983-10-18
• [EN] TARGETED DRUG RESCUE WITH NOVEL COMPOSITIONS, COMBINATIONS, AND METHODS THEREOF<br/>[FR] TARGETED DRUG RESCUE AVEC DE NOUVELLES COMPOSITIONS, ASSOCIATIONS ET PROCÉDÉS CORRESPONDANTS
  申请人：EXCIVA UG HAFTUNGSBESCHRAENKT

  公开号：WO2018204713A1

  公开（公告）日：2018-11-08

  Compounds of Formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, metabolites thereof, derivatives thereof, prodrugs thereof, acid addition salts thereof, pharmaceutically acceptable salts thereof, or N-oxides thereof; or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided. Pharmaceutical compositions comprising a compound of Formula I, or enantiomers thereof, metabolites thereof, derivatives thereof, prodrugs thereof, acid addition salts thereof, pharmaceutically acceptable salts thereof, or N-oxides thereof; or a combination thereof, wherein the compound is double and/or triple agent or ligand for CYP2D6, 5-HT2A, and/or 5HT2C receptors, and/or acetylcholinesterase are provided.