2-Chlor-6-methyl-N-methyl-anilin | 19957-42-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chlor-6-methyl-N-methyl-anilin
• 英文别名: 2-chloro-N,6-dimethylaniline
• CAS: 19957-42-7
• 化学式: C₈H₁₀ClN
• 分子量: 155.627
• InChiKey: FWQUBKZCULDUQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Chlor-6-methyl-N-methyl-anilin 在 吡啶 、 N-hydroxy pivalamide 、 一氧化碳 、 palladium diacetate 、 caesium carbonate 、 正丁基二(1-金刚烷基)膦 作用下， 以 二氯甲烷 、 均三甲苯 为溶剂， 反应 3.0h， 生成 7-chloro-1-methylindolin-2-one
  参考文献：
  名称：

  化学选择性C（sp3）对钯催化的酰胺化反应？H活化：使用氨基甲酰氯前驱体的简明路线到吲哚

  摘要：

  颇为选择：一个新的战略是为各种羟吲哚从氨基甲酰氯综合方法。在最佳反应条件下，以Ad 2 PBu为配体，t BuCONHOH为添加剂，并在CO气氛下，在C（sp 2）H键的存在下进行选择性C（sp 3）H活化。Ad =金刚烷基。

  DOI：

  10.1002/anie.201108889

文献信息

• POTASSIUM CHANNEL MODULATORS
  申请人：Cadent Therapeutics, Inc.

  公开号：US20170355708A1

  公开（公告）日：2017-12-14

  Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.

  提供的是公式(I)的新颖化合物： 以及它们的药用可接受盐，这些化合物用于治疗与钾通道相关的一系列疾病、障碍或状况。还提供了包含公式(I)的新颖化合物的药物组合物，它们的药用可接受盐，以及使用它们来治疗与钾通道相关的一种或多种疾病、障碍或状况的方法。
• Transition Metal-Catalyzed C-H Amination Using Unactivated Amines
  申请人：Warren Timothy H.

  公开号：US20110213146A1

  公开（公告）日：2011-09-01

  One aspect of the invention relates to a method of animation or amidation, comprising the step of combining a substrate, comprising a reactive C—H bond, and an amine or amide, comprising a reactive N—H bond, in the presence of an oxidizing agent and a metal-containing catalyst, thereby forming a product with a covalent bond between the carbon of the reactive C—H bond and the nitrogen of the reactive N—H bond.

  发明的一个方面涉及一种动画或酰胺化方法，包括将包含反应性C—H键的底物与包含反应性N—H键的胺或酰胺，在氧化剂和含金属催化剂的存在下结合，从而形成具有反应性C—H键的碳与反应性N—H键的氮之间的共价键的产物。
• COMPOUNDS FOR THE MODULATION OF PPARgamma ACTIVITY
  申请人：McGee Lawrence R.

  公开号：US20100113522A1

  公开（公告）日：2010-05-06

  Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.

  提供了PPARγ活性调节剂，可用于制备药物组合物和治疗2型糖尿病和肥胖等疾病的方法。
• COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：US20220389027A1

  公开（公告）日：2022-12-08

  Provided is a compound of Formula 1: wherein: X and Y are independently O, S, or CZ1Z2; Ring A is a benzene or naphthalene ring; A1 to A4 are independently hydrogen, deuterium, a halogen group, a cyano group, a nitro group, a hydroxyl group, or a substituted or unsubstituted: alkyl, cycloalkyl, aryl, or heterocyclic group; R1 to R6, Z1, and Z2 are independently a substituted or unsubstituted: alkyl, aryl, or heterocyclic group; n1 to n3, m, and l are 0 or 1 and n1+n2+n3 is ≥2; a1 and a2 are 1 to 4; a3 is 1 to 3; a4 is 1 to 6; and when a1 to a4 are each 2 or higher, structures in the parenthesis are the same or different, provided that when Ring A is naphthalene, m is 0, and when l is 1, Ring A is a benzene ring, and an organic light-emitting device comprising the compound.
• US4117165A
  申请人：——

  公开号：US4117165A

  公开（公告）日：1978-09-26