1-ethyl-N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)propoxy)phenylsulfonyl)piperidine-4-carboxamide | 476186-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-ethyl-N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)propoxy)phenylsulfonyl)piperidine-4-carboxamide
• 英文别名: 1-ethyl-N-hydroxy-4-[4-[3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonylpiperidine-4-carboxamide
• CAS: 476186-06-8
• 化学式: C₂₆H₂₉F₃N₄O₇S
• 分子量: 598.6
• InChiKey: NVQGQIYFJRAZLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  1-ethyl-4-((4-(3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)propoxy)phenyl)sulfonyl)piperidine-4-carboxylic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 乙酰氯 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成 1-ethyl-N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)propoxy)phenylsulfonyl)piperidine-4-carboxamide
  参考文献：
  名称：

  MMP-13 selective α-sulfone hydroxamates: A survey of P1′ heterocyclic amide isosteres

  摘要：

  Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups. (1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in an effort to improve half-life. We identify a hydroxamate tetrazole 4e that spares MMP-1 and -14, shows >400-fold selectivity versus MMP-8 and >600-fold selectivity versus MMP-2, and has a 4.8 h half-life in rats. X-ray data (1.9 angstrom) for tetrazole 4c is presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.099

文献信息

• [EN] AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS<br/>[FR] ACIDES HYDROXAMIQUES SULFONIQUES AROMATIQUES ET LEUR UTILISATION COMME INHIBITEURS DE LA PROTEASE
  申请人：PHARMACIA CORP

  公开号：WO2004043943A1

  公开（公告）日：2004-05-27

  This invention is directed to aromatic sulfone hydroxamic acids (including aromatic sulfone hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
• MMP-13 selective α-sulfone hydroxamates: A survey of P1′ heterocyclic amide isosteres
  作者：Thomas E. Barta、Daniel P. Becker、Louis J. Bedell、Alan M. Easton、Susan L. Hockerman、James Kiefer、Grace E. Munie、Karl J. Mathis、Madeleine H. Li、Joseph G. Rico、Clara I. Villamil、Jennifer M. Williams

  DOI：10.1016/j.bmcl.2011.03.099

  日期：2011.5

  Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups. (1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in an effort to improve half-life. We identify a hydroxamate tetrazole 4e that spares MMP-1 and -14, shows >400-fold selectivity versus MMP-8 and >600-fold selectivity versus MMP-2, and has a 4.8 h half-life in rats. X-ray data (1.9 angstrom) for tetrazole 4c is presented. (C) 2011 Elsevier Ltd. All rights reserved.