(E)-1,2-bis(N-indolyl)ethene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-1,2-bis(N-indolyl)ethene
• 英文别名: 1-[2-(1H-Indol-1-yl)ethenyl]-1H-indole；1-[(E)-2-indol-1-ylethenyl]indole
• 化学式: C₁₈H₁₄N₂
• 分子量: 258.323
• InChiKey: PQGHBXLNJRUUSB-BUHFOSPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  吲哚 、 1,2-二碘乙烯 在 copper(l) iodide 、 caesium carbonate 、 N,N'-二甲基乙二胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以72%的产率得到(E)-1,2-bis(N-indolyl)ethene
  参考文献：
  名称：

  Copper-catalyzed β-Iodovinylation of Azole and Pyrrole Derivatives

  摘要：

  Herein is described an efficient copper-catalyzed synthesis of beta-iodovinyl-azole and beta-iodovinyl-pyrrole derivatives using (E)-1,2-diiodoethene which was efficiently applied to azole and pyrrole derivatives in both organic and hydro-organic medium to afford the corresponding beta-iodovinylated adducts in up to excellent yields with complete stereocontrol. These nitrogenated vinyl iodides can be further functionalized into disubstituted olefins through various metal catalyzed coupling reactions.

  DOI：

  10.3987/com-20-14234

文献信息

• Copper-catalyzed β-Iodovinylation of Azole and Pyrrole Derivatives
  作者：Benoit Daoust、Simon Ricard、François Ladouceur、Guillaume Couture

  DOI：10.3987/com-20-14234

  日期：——

  Herein is described an efficient copper-catalyzed synthesis of beta-iodovinyl-azole and beta-iodovinyl-pyrrole derivatives using (E)-1,2-diiodoethene which was efficiently applied to azole and pyrrole derivatives in both organic and hydro-organic medium to afford the corresponding beta-iodovinylated adducts in up to excellent yields with complete stereocontrol. These nitrogenated vinyl iodides can be further functionalized into disubstituted olefins through various metal catalyzed coupling reactions.