1-(4-ethoxybuta-1,3-dien-2-yl)cyclohexene | 1140971-75-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-ethoxybuta-1,3-dien-2-yl)cyclohexene
• CAS: 1140971-75-0
• 化学式: C₁₂H₁₈O
• 分子量: 178.274
• InChiKey: KFSNMRDCTYRAOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-乙炔基环己烷 、 乙烯基乙醚 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 copper(II) sulfate 作用下， 以 水 、 叔丁醇 为溶剂， 反应 0.5h， 以48%的产率得到(E)-3-Cyclohex-1-enyl-but-2-enal
  参考文献：
  名称：

  Alkyne-Enol Ether Cross-Metathesis in the Presence of CuSO₄: Direct Formation of 3-Substituted Crotonaldehydes in Aqueous Medium

  摘要：

  An efficient synthesis of 3-substituted crotonaldehydes via alkyne-enol ether cross-metathesis in the presence of CuSO4 and in aqueous medium was developed. Crotonaldehydes were obtained in good yields from terminal aryl-alkynes as well as from terminal alkyl-alkynes. All of the reactions were carried out under microwave irradiation and were completed in a few minutes. Water was used as the cosolvent, making c, this approach safer, economic, and desiderable from an enviromental point of view.

  DOI：

  10.1021/jo900205x

文献信息

• Alkyne-Enol Ether Cross-Metathesis in the Presence of CuSO₄: Direct Formation of 3-Substituted Crotonaldehydes in Aqueous Medium
  作者：Daniele Castagnolo、Lorenzo Botta、Maurizio Botta

  DOI：10.1021/jo900205x

  日期：2009.4.17

  An efficient synthesis of 3-substituted crotonaldehydes via alkyne-enol ether cross-metathesis in the presence of CuSO4 and in aqueous medium was developed. Crotonaldehydes were obtained in good yields from terminal aryl-alkynes as well as from terminal alkyl-alkynes. All of the reactions were carried out under microwave irradiation and were completed in a few minutes. Water was used as the cosolvent, making c, this approach safer, economic, and desiderable from an enviromental point of view.