(3R,5R,6S,7S,9R,11E,13R,14R)-6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-3,5,7,9,13-pentamethyl-1-oxacyclotetradec-11-ene-2,4,10-trione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,5R,6S,7S,9R,11E,13R,14R)-6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-3,5,7,9,13-pentamethyl-1-oxacyclotetradec-11-ene-2,4,10-trione
• 化学式: C₂₈H₄₇NO₇
• 分子量: 509.7
• InChiKey: OXFYAOOMMKGGAI-MUVJKRCBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] ANTIBACTERIAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIBACTÉRIENS
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2019199979A1

  公开（公告）日：2019-10-17

  The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided.

  本申请提供了以下化合物的公式：还提供了使用这些化合物杀灭细菌生长和治疗细菌感染的方法。
• [EN] ANTIMICROBIAL AGENTS AND COMPOSITIONS AND USES THEREOF<br/>[FR] AGENTS ANTIMICROBIENS, COMPOSITIONS ASSOCIÉES ET LEURS UTILISATIONS
  申请人：CHEMIC LABORATORIES INC

  公开号：WO2021055506A1

  公开（公告）日：2021-03-25

  Described herein are compounds that act as antimicrobial agents, compositions comprising these compounds, and methods of their use in to treating infections caused by Helicobacter pylori (H. pylori) or killing or inhibititing the growth of H. pylori.

  本文描述了作为抗微生物剂的化合物，包括这些化合物的组合物，以及它们在治疗由幽门螺杆菌（H. pylori）引起的感染或杀灭或抑制幽门螺杆菌生长的方法。
• METHOD FOR PRODUCING AVENACIOLIDES AND USES THEREOF
  申请人：Academia Sinica

  公开号：US20160297829A1

  公开（公告）日：2016-10-13

  Disclosed herein are novel uses of avenaciolide derivatives and the preparation method of producing the same. The avenaciolide derivatives may suppress or inhibit the growth of gram-positive bacteria, including the notorious methicillin-resistant Staphylococcus aureus . Accordingly, the avenaciolides derivatives are potential lead compounds for the development of next generation antibiotics for the treatment of disease and/or disorders related to infection caused by gram-positive bacteria.

  本发明公开了avenaciolide衍生物的新用途及其制备方法。这些avenaciolide衍生物能够抑制或阻断革兰氏阳性细菌的生长，包括臭名昭著的耐甲氧西林金黄色葡萄球菌。因此，avenaciolide衍生物是开发下一代抗生素的潜在先导化合物，用于治疗由革兰氏阳性细菌引起的感染相关疾病和/或紊乱。
• Bio-intermediates for use in the chemical synthesis of polyketides
  申请人：——

  公开号：US20040018598A1

  公开（公告）日：2004-01-29

  The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKS”) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediates”) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greatly simplified.

  本发明涉及由一个或多个聚酮合酶合成酶（“PKS”）基因的子模块制备的化合物，这些化合物作为起始物质用于化学合成新颖分子，特别是天然存在的聚酮类化合物或其衍生物。生物衍生的中间体（“生物中间体”）通常代表着尤其难以使用传统化学方法合成的化合物，因为其中一个或多个立体中心。在本发明的一个方面，提供了用于累积素合成的中间体，该中间体进入Danishefsky及其同事的合成方案。在本发明的另一个方面，提供了用于二十碳二烯酮合成的中间体，这些中间体进入Smith及其同事的合成方案。通过利用生物过程固有的立体化学特异性，关键中间体的合成以及诸如累积素和二十碳二烯酮等化合物的整体合成大大简化了。
• [EN] BRIDGED MACROCYCLIC COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] COMPOSES MACROCYCLIQUES PONTES ET PROCEDES DE PREPARATION DESDITS COMPOSES
  申请人：ENANTA PHARM INC

  公开号：WO2005080408A1

  公开（公告）日：2005-09-01

  The present invention provides a method for preparing bridged macrocyclic compounds comprising the step of reacting a macrocyclic compound characterized by having at least two nucleophilic moieties with a bifunctional bridging reagent optionally in the presence of a catalyst, thereby producing a bridged macrocyclic product.

  本发明提供了一种制备桥联大环化合物的方法，包括以下步骤：将至少具有两个亲核基团的大环化合物与双功能桥接试剂反应，可选地在催化剂的存在下进行，从而产生桥联大环产物。