申请人:Efrat Biopolymers Ltd.
公开号:US20040161464A1
公开(公告)日:2004-08-19
Poly(ester-anhydrides) or polyesters formed from ricinoleic acid and natural fatty diacids and their method of preparation and its use for delivering bioactive agents including small drug molecules, peptides and proteins, DNA and DNA complexes with cationic lipids or polymers or nano and microparticles loaded with bioactive agents are disclosed herein. The drug delivery compositions are administered to a patient in a liquid form, increase in viscosity in vivo to form a drug depot or implant, and are able to release the incorporated bioactive agent for weeks. In the preferred embodiment, the drug delivery formulations are administered by injection. In one embodiment, the compositions are suitable for local or regional delivery of drugs to diseased sites, such as treating solid tumors and bone infections. In a preferred embodiment, the drug delivery compositions are suitable for site-specific chemotherapy for the treatment of solid tumors including: squamous cell carcinoma (SCC) of the head and neck, prostate cancer, and sarcomas for intratumoral injection or insertion.
本文公开了由蓖麻油酸和天然脂肪二酸形成的聚酯酸酐或聚酯以及它们的制备方法,以及它们用于输送生物活性剂,包括小分子药物、肽和蛋白质、DNA和带阳离子脂质或聚合物或纳米和微粒子的DNA复合物。这些药物输送组合物以液态形式给患者使用,在体内粘度增加形成药物库或植入物,并能够持续释放所包含的生物活性剂达数周之久。在首选实施例中,药物输送配方通过注射给予。在一个实施例中,该组合物适用于将药物局部或区域性输送到疾病部位,例如治疗实体肿瘤和骨感染。在首选实施例中,药物输送组合物适用于针对实体肿瘤的特定部位化疗,包括头颈鳞状细胞癌(SCC)、前列腺癌和肉瘤的肿瘤内注射或插入。