decanoyl(-3)Fruf(b2-1a)Glc

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: decanoyl(-3)Fruf(b2-1a)Glc
• 英文别名: [(2S,3S,4R,5R)-4-hydroxy-2,5-bis(hydroxymethyl)-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-3-yl] decanoate
• 化学式: C₂₂H₄₀O₁₂
• 分子量: 496.5
• InChiKey: OXTQCKINYRBPJS-LUQRLMJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  196
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20170000888A1

  公开（公告）日：2017-01-05

  Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

  描述了包括凝胶剂的自组装凝胶组合物，例如，一种酶可切割的凝胶剂，例如，具有分子量不超过2500的凝胶剂。这些自组装凝胶组合物可以包裹一个或多个药剂。还描述了制备这些自组装凝胶组合物的方法，以及使用这些自组装凝胶组合物进行药物传递的方法。
• [EN] C-GLYCOSIDE AMINE DERIVATIVES AND METHODS OF MAKING<br/>[FR] DÉRIVÉS D'AMINE DE C-GLYCOSIDE ET LEURS PROCÉDÉS DE FABRICATION
  申请人：US AGRICULTURE

  公开号：WO2021141979A1

  公开（公告）日：2021-07-15

  Disclosed are C-glycoside amine derivatives of the formula: R-CH2-C(CH3)-NH-R2 wherein R is a saccharide (e.g., as described in U.S. Patent 8,314,219) and R2 is an acyl moiety derived from any ketone of the formula R3-C(O)-R3 wherein R3 is C1 to C22 straight or branched chain hydrocarbon which may be saturated or unsaturated. In addition, a method for making the C-glycoside amine derivatives involving (1) reacting a saccharide (e.g., glucose) C-glycoside ketone with a catalyst (e.g., Rh), about 10 to about 25 fold excess NH3, and an organic solvent (e.g., methanol) to form a saccharide C-glycoside amine, and (2) reacting said saccharide C-glycoside amine with a catalyst (e.g., Rh), an organic solvent (e.g., methanol), and an acyl moiety derived from any ketone of the formula R3-C(O)-R3 wherein R3 is C1 to C22 straight or branched chain hydrocarbon which may be saturated or unsaturated to form said C-glycoside amine derivative.

  本发明公开了C-糖苷胺衍生物的结构式：R-CH2-C(CH3)-NH-R2，其中R是一种糖苷（例如，如美国专利8,314,219所述），而R2是从任何公式为R3-C（O）-R3的酮中派生的酰基基团，其中R3是C1到C22的直链或支链烃基，可以是饱和的或不饱和的。此外，本发明还公开了一种制备C-糖苷胺衍生物的方法，包括（1）将糖苷（例如葡萄糖）C-糖苷酮与催化剂（例如Rh）、约10到约25倍过量的NH3和有机溶剂（例如甲醇）反应，以形成糖苷C-糖苷胺，以及（2）将所述糖苷C-糖苷胺与催化剂（例如Rh）、有机溶剂（例如甲醇）和从任何公式为R3-C（O）-R3的酮中派生的酰基基团（其中R3是C1到C22的直链或支链烃基，可以是饱和的或不饱和的）反应，以形成所述C-糖苷胺衍生物。
• Polyglycerols and production thereof
  申请人：Endo Toshio

  公开号：US20070049775A1

  公开（公告）日：2007-03-01

  A polyglycerol composition contains diglycerol, triglycerol, and tetraglycerol each in a content of 5 percent by weight or more, has a total content of diglycerol, triglycerol, and tetraglycerol of 75 percent by weight or more, has a total content of higher polyglycerol components of 10 percent by weight or less, the higher polyglycerol components each having a degree of polymerization of 7 or higher, and is substantially free from chlorine atom. A process prepares a polyglycerol composition by reacting glycerol and/or a polyglycerol with glycidol in the presence of an activated carbon catalyst.

  一种聚甘油组合物，其中二甘油、三甘油和四甘油的含量均达到重量的5％或更多，其二甘油、三甘油和四甘油的总含量达到重量的75％或更多，高聚甘油成分的总含量不超过重量的10％，高聚甘油成分的聚合度均达到7或更高，并且基本上不含氯原子。一种方法通过在活性炭催化剂存在下将甘油和/或聚甘油与环氧丙烷反应来制备聚甘油组合物。
• [EN] SELF-ASSEMBLED GELS FORMED WITH ANTI-RETROVIRAL DRUGS, PRODRUGS THEREOF, AND PHARMACEUTICAL USES THEREOF<br/>[FR] GELS AUTO-ASSEMBLÉS FORMÉS AVEC DES MÉDICAMENTS ANTI-RÉTROVIRAUX, LEURS PROMÉDICAMENTS ET LEURS UTILISATIONS PHARMACEUTIQUES
  申请人：BRIGHAM & WOMENS HOSPITAL INC

  公开号：WO2018144991A1

  公开（公告）日：2018-08-09

  Self-assembled gels and methods of making thereof are described. A selective range of ratios between an organic solvent and optionally water, or an aqueous solution, allows for combinations of gelators (such as GRAS amphiphiles or prodrug-based gelators), co-gelators (such as anti-retrovirals), and solvents to form self-supporting hydrogels or organogels. The resulting gels may be used in methods of treating HIV and/or hepatitis.

  本文描述了自组装凝胶及其制备方法。有机溶剂和可选的水或水溶液之间的选择性比例范围，允许凝胶剂（例如GRAS两性分子或前药基凝胶剂）、共聚凝胶剂（例如抗逆转录病毒药物）和溶剂组合形成自支撑水凝胶或有机凝胶。所得到的凝胶可以用于治疗HIV和/或肝炎的方法。
• Production Of Inorganic-Organic Composite Materials By Reactive Spray-Drying
  申请人：BASF SE

  公开号：US20140228334A1

  公开（公告）日：2014-08-14

  Process for producing composite materials by reactive spray-drying, where a liquid phase A, which comprises inorganic cations, and a liquid phase B, which comprises anions which, with the inorganic cations, form a salt that is insoluble in the mixture of the liquid phases are sprayed together using at least one multi-substance nozzle, and where at least one hydrophobic active ingredient is present in dissolved form in at least one liquid spraying phase, and where the salt formed from the cations of phase A and the anions of phase B has a solubility of less than 0.02 mol/l in the neutral aqueous medium.

  使用反应性喷雾干燥制备复合材料的过程，其中液相A包含无机阳离子，液相B包含阴离子，与无机阳离子形成不溶于液相混合物的盐，两种液相使用至少一个多组分喷嘴同时喷射，至少一个疏水性活性成分以溶解形式存在于至少一种液体喷雾相中，由A相的阳离子和B相的阴离子形成的盐在中性水介质中的溶解度小于0.02mol/L。