Erythromycin sulfate | 7184-72-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Erythromycin sulfate
• 英文别名: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;sulfuric acid
• CAS: 7184-72-7
• 化学式: C37H69NO17S
• 分子量: 832.0
• InChiKey: XTSSJGRRFMNXGO-YZPBMOCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.13
• 重原子数：
  56
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  277
• 氢给体数：
  7
• 氢受体数：
  18

文献信息

• Novel compositions
  申请人：Malvern Cosmeceutics Limited

  公开号：EP2428200A2

  公开（公告）日：2012-03-14

  A composition comprising lipid and surfactant, characterised in that the surfactant has an HLB number of less than 20 and in that the lipid and surfactant are in the form of macromolecular assemblies of less than 100 nm in diameter.

  一种由脂质和表面活性剂组成的组合物，其特征在于表面活性剂的 HLB 值小于 20，脂质和表面活性剂呈直径小于 100 纳米的大分子集合体形式。
• Oriented P4HB implants containing antimicrobial agents
  申请人：Tepha, Inc.

  公开号：US10874771B2

  公开（公告）日：2020-12-29

  Oriented resorbable implants made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof, have been developed that contain one or more antimicrobial agents to prevent colonization of the implants, and reduce or prevent the occurrence of infection following implantation in a patient. These oriented implants are particularly suitable for use in procedures where prolonged strength retention is necessary and there is a risk of infection. Coverings and receptacles made from poly-4-hydroxybutyrate and copolymers thereof, containing antimicrobial agents, have also been developed for use with implantable devices to prevent colonization of these devices, and to reduce or prevent the occurrence of infection following implantation of these devices in a patient. These coverings and receptacles may be used to hold, or partially or fully cover, devices such as pacemakers and neurostimulators. Preferably, the coverings and receptacles are made from meshes, non-wovens, films, fibers, and foams, and contain rifampin and minocycline.

  由聚-4-羟基丁酸酯（P4HB）及其共聚物制成的定向可吸收植入物已经研制成功，这种植入物含有一种或多种抗菌剂，可防止植入物的定植，减少或防止植入病人体内后发生感染。这些定向植入物尤其适用于需要长时间保持强度且有感染风险的手术。由聚-4-羟基丁酸及其共聚物制成的、含有抗菌剂的覆盖物和容器也已开发出来，可与植入式装置一起使用，以防止这些装置发生定植，并减少或防止病人植入这些装置后发生感染。这些覆盖物和容器可用于固定、部分或全部覆盖心脏起搏器和神经刺激器等装置。这些覆盖物和容器最好由网格布、无纺布、薄膜、纤维和泡沫制成，并含有利福平和米诺环素。
• COMPOSITIONS COMPRISING A LIPID AND COPOLYMER OF STYRENE AND MALEIC ACID
  申请人：Malvern Cosmeceutics Limited

  公开号：EP1890675A1

  公开（公告）日：2008-02-27
• COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT
  申请人：Malvern Cosmeceutics Limited

  公开号：EP2099410A2

  公开（公告）日：2009-09-16
• Compositions comprising a lipid and copolymer of styrene and maleic acid
  申请人：Tonge Stephen

  公开号：US20090155375A1

  公开（公告）日：2009-06-18

  A composition comprising a lipid and copolymer of styrene and maleic acid, wherein the copolymer of styrene and maleic acid is non-alternating, and wherein the polymer and lipid are in the form of macromolecular assemblies.