Cyclohexenediol | 141607-99-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cyclohexenediol
• 英文别名: cyclohex-2-ene-1,1-diol
• CAS: 141607-99-0
• 化学式: C₆H₁₀O₂
• 分子量: 114.14
• InChiKey: RVJVAMZRPQBPEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Synthetic route to dronabinol
  申请人：Souza E.S. Fabio

  公开号：US20060074252A1

  公开（公告）日：2006-04-06

  Dronabinol, the tetrahydrocannabinol compound which comprises the active constituent of marijuana and is pharmaceutically useful as an antiemetic, is prepared by a process involving reaction of cis-menth-1-enc-3,8-diol with olivetol to form 1,3-dihydroxy-2-[(1R,6R)-6-(2-hydroxyprop-2-yl)-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene; and cyclizing the 1,3-dihydroxy-2-[(1R,6R)-6-(2-hydroxyprop-2-yl)-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene so formed to obtain dronabinol. A novel synthesis of cis-menth-1-ene-3,8-diolis also provided.

  Dronabinol，这是大麻的活性成分四氢大麻酚化合物，作为一种抗恶心药物在药学上有用，是通过将顺-薄荷-1-烯-3,8-二醇与橄榄酚反应制备的，形成1,3-二羟基-2-[(1R,6R)-6-(2-羟基丙-2-基)-3-甲基环己-2-烯-1-基]-5-戊基苯；然后将所得的1,3-二羟基-2-[(1R,6R)-6-(2-羟基丙-2-基)-3-甲基环己-2-烯-1-基]-5-戊基苯环化，以获得dronabinol。同时还提供了一种新的合成顺-薄荷-1-烯-3,8-二醇的方法。
• Catalysts
  申请人：Econic Technologies Ltd

  公开号：US20170210848A1

  公开（公告）日：2017-07-27

  The present invention relates to the field of polymerisation catalysts, and systems comprising said catalysts for polymerising carbon dioxide and an epoxide, a lactide and/or lactone, and/or an epoxide and an anhydride. The catalyst is of formula (I): Wherein M 1 and M 2 are independently selected from Zn(II), Cr(II), Co(II), Cu(II), Mn(II), Ni(II), Mg(II), Fe(II), Ti(II), V(II), Cr(III)-X, Co(III)-X, Ni(III)-X, Mn(III)-X, Fe(III)-X, Ca(II), Ge(II), Al(III)-X, Ti(III)-X, V(III)-X, Ge(IV)-(X) 2 or Ti(IV)-(X) 2 . R 3A is different from R 3B ; and/or at least one occurrence of E 3 , E 4 , E 5 and E 6 is different to a remaining occurrence of E 3 , E 4 , E 5 and E 6 . A ligand, a process of asymmetric N-substitution of a symmetrical ligand and a process for the reaction of: (i) carbon dioxide with an epoxide; (ii) an epoxide and an anhydride; and/or (iii) a lactide and/or a lactone, in the presence of a catalyst is also described.

  本发明涉及聚合催化剂领域，以及包括所述催化剂的系统，用于聚合二氧化碳和环氧化物，内酯和/或内酯，以及环氧化物和酸酐。催化剂的化学式为（I）：其中M1和M2分别选自Zn（II）、Cr（II）、Co（II）、Cu（II）、Mn（II）、Ni（II）、Mg（II）、Fe（II）、Ti（II）、V（II）、Cr（III）-X、Co（III）-X、Ni（III）-X、Mn（III）-X、Fe（III）-X、Ca（II）、Ge（II）、Al（III）-X、Ti（III）-X、V（III）-X、Ge（IV）-（X）2或Ti（IV）-（X）2。R3A与R3B不同；和/或至少有一个E3、E4、E5和E6的出现与其余的E3、E4、E5和E6的出现不同。还描述了一种配体、对称配体的不对称N-取代的过程以及在催化剂存在下进行以下反应的过程：（i）二氧化碳与环氧化物；（ii）环氧化物和酸酐；和/或（iii）内酯和/或内酯。
• METHODS FOR FORMING POLYCARBONATE ETHER POLYOLS AND HIGH MOLECULAR WEIGHT POLYETHER CARBONATES
  申请人：Econic Technologies LTD.

  公开号：US20200339749A1

  公开（公告）日：2020-10-29

  The method of preparing the polycarbonate ether polyol or high molecular weight polyether carbonate using controlled addition of materials during polymerisation includes the steps of: mixing catalyst of formula(I), double metal cyanide (DMC) catalyst and optionally carbon dioxide and/or solvent with epoxide and optionally starter compound and/or carbon dioxide; or mixing DMC catalyst and optionally starter compound, carbon dioxide and/or solvent with epoxide and optionally carbon dioxide and/or solvent; or mixing epoxide, catalyst of formula(I), starter compound and carbon dioxide and optionally solvent; or mixing catalyst of formula (I), DMC catalyst and optionally starter compound, epoxide, carbon dioxide and/or solvent to form in each case a mixture (α); and adding one or more of starter compound, epoxide, carbon dioxide, catalyst of formula(I), DMC catalyst and/or solvent to mixture (α) to form mixture (β) comprising starter compound, epoxide, carbon dioxide, catalyst of formula(I), DMC catalyst and optionally solvent,

  使用控制添加材料的方法制备聚碳酸醚聚醚多元醇或高分子量聚醚碳酸酯，包括以下步骤：将配方（I）的催化剂、双金属氰化物（DMC）催化剂和可选的二氧化碳和/或溶剂与环氧化合物和可选的起始剂和/或二氧化碳混合；或将DMC催化剂和可选的起始剂、二氧化碳和/或溶剂与环氧化合物和可选的二氧化碳和/或溶剂混合；或将环氧化合物、配方（I）的催化剂、起始剂和二氧化碳和可选的溶剂混合；或将配方（I）的催化剂、DMC催化剂和可选的起始剂、环氧化合物、二氧化碳和/或溶剂混合，以在每种情况下形成混合物（α）；并向混合物（α）中添加一个或多个起始剂、环氧化合物、二氧化碳、配方（I）的催化剂、DMC催化剂和/或溶剂，以形成混合物（β），其中包括起始剂、环氧化合物、二氧化碳、配方（I）的催化剂、DMC催化剂和可选的溶剂。
• INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF DRONABINOL
  申请人：SOUZA Fabio E.S.

  公开号：US20080312465A1

  公开（公告）日：2008-12-18

  Dronabinol, the tetrahydrocannabinol compound which comprises the active constituent of marijuana and is pharmaceutically useful as an antiemetic, is prepared by a process involving reaction of cis-menth-1-ene-3,8-diol with olivetol to form 1,3-dihydroxy-2-[(1R,6R)-6-(2-hydroxyprop-2-yl)-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene; and cyclizing the 1,3-dihydroxy-2-[(1R,6R)-6-(2-hydroxypropr-2-yl)-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene so formed to obtain dronabinol. A novel synthesis of cis-menth-1-ene-3,8-diol is also provided.

  Dronabinol是四氢大麻酚化合物，它是大麻的活性成分，并且在药学上用作止吐剂，该化合物的制备涉及使用顺-薄荷烯-3,8-二醇与橄榄酚反应，形成1,3-二羟基-2-[(1R,6R)-6-(2-羟基丙基)-3-甲基环己-2-烯-1-基]-5-戊基苯; 并将形成的1,3-二羟基-2-[(1R,6R)-6-(2-羟基丙基)-3-甲基环己-2-烯-1-基]-5-戊基苯环化以获得Dronabinol。此外还提供了一种新的合成顺-薄荷烯-3,8-二醇的方法。
• ADVANCED POLY EPOXY ESTER RESIN COMPOSITIONS
  申请人：Jin Xin

  公开号：US20130178591A1

  公开（公告）日：2013-07-11

  A poly epoxy ester resin composition of the following chemical structure: where n is a number from 2 to about 3000; each m independently has a value of 0 or 1; each R 0 is independently —H or —CH 3 ; each R 1 is independently —H or a C 1 to C 6 alkylene radical (saturated divalent aliphatic hydrocarbon radical), Ar is a divalent aryl group or heteroarylene group;_and X is cycloalkylene group, including substituted cycloalkylene group, where the substitute group include an alkyl, cycloalkyl, an aryl or an aralkyl group or other substitute group, for example, a halogen, a nitro, a blocked isocyanate, or an alkyloxy group; the combination of cycloalkylene and alkylene groups and the combination of alkylene and cycloalkylene group with a bridging moiety in between.

  以下是化学结构式为的聚合物环氧酯树脂组成：其中n为2至约3000的数字；每个m独立地具有值为0或1；每个R0独立地为—H或—CH3；每个R1独立地为—H或C1到C6的烷基基团（饱和二价脂肪族碳氢基团），Ar为二价芳基基团或杂芳基基团；X为环烷基团，包括取代环烷基团，其中取代基团包括烷基、环烷基、芳基或芳基烷基团或其他取代基团，例如卤素、硝基、阻塞异氰酸酯或烷氧基团；环烷基和烷基团的组合以及烷基和环烷基团之间带有桥接基团。