(4-Chlorophenyl)-[1-[4-(pyridin-4-ylmethyl)piperazine-1-carbonyl]piperidin-4-yl]methanone | 416849-59-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-Chlorophenyl)-[1-[4-(pyridin-4-ylmethyl)piperazine-1-carbonyl]piperidin-4-yl]methanone
• CAS: 416849-59-7
• 化学式: C₂₃H₂₇ClN₄O₂
• 分子量: 426.946
• InChiKey: INLPWDJMSIKNKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  56.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-pyridin-4-ylmethyl-piperazine hydrochloric acid salt 、 三光气 、 4-(4-氯苯甲酰基)哌啶盐酸盐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 50.0h， 以55%的产率得到(4-Chlorophenyl)-[1-[4-(pyridin-4-ylmethyl)piperazine-1-carbonyl]piperidin-4-yl]methanone
  参考文献：
  名称：

  WO2008/108957

  摘要：

  公开号：

文献信息

• NOVEL NON-IMIDAZOLE COMPOUNDS
  申请人：Aslanian Robert G.

  公开号：US20080119487A1

  公开（公告）日：2008-05-22

  Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H 1 receptor antagonist.
• PIPERIDINYL-PIPERIDINE AND PIPERAZINYL-PIPERIDINE FOR USE IN THE TREATMENT OF DIABETES OR PAIN
  申请人：Aslanian Robert G.

  公开号：US20100093692A1

  公开（公告）日：2010-04-15

  The present invention relates to Compounds of Formula (I), compositions comprising the compounds, and methods of using the compounds to treat or prevent pain, diabetes, a diabetic complication, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) in a patient.
• US7300941B2
  申请人：——

  公开号：US7300941B2

  公开（公告）日：2007-11-27
• WO2008/108957
  申请人：——

  公开号：——

  公开（公告）日：——