3',5'-Difluoro-4'-methylacetophenone | 1256352-98-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3',5'-Difluoro-4'-methylacetophenone
• 英文别名: 1-(3,5-difluoro-4-methylphenyl)ethanone
• CAS: 1256352-98-3
• 化学式: C₉H₈F₂O
• 分子量: 170.16
• InChiKey: JGHQVTTVLCUHGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
  申请人：GLAXOSMITHKLINE LLC

  公开号：US20150152108A1

  公开（公告）日：2015-06-04

  The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本发明涉及新型取代桥式脲化合物，相应的相关类似物，药物组合物以及其使用方法。本发明的抑制素调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和疾病，包括但不限于与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块疾病、炎症、癌症和/或潮红有关的疾病或疾病，以及那些会受益于增加线粒体活性的疾病或疾病。本发明还涉及包含抑制素调节化合物与另一治疗剂组合的组合物。
• PHENYLPYRAZOLE COMPOUND AND METHOD FOR CONTROLLING PLANT DISEASE
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20210321614A1

  公开（公告）日：2021-10-21

  The present invention provides a method for controlling a plant disease which comprises applying a compound represented by formula (I) [wherein Z represents a C1-C6 chain hydrocarbon group and the like, R 1 and R 2 are identical to or different from each other and represent a hydrogen atom or a fluorine atom, and R 3 , R 4 , R 5 , R 6 and R 7 are identical to or different from each other and represent a C1-C6 chain hydrocarbon group and the like] to a plant or a soil, which has excellent control efficacies against plant diseases.

  本发明提供了一种用于控制植物疾病的方法，包括将由式（I）表示的化合物应用于植物或土壤，其中Z代表C1-C6链烃基等，R1和R2相同或不同，代表氢原子或氟原子，R3、R4、R5、R6和R7相同或不同，代表C1-C6链烃基等，该方法对植物疾病具有优异的控制效果。
• Substituted Aryl-Fluoroborates as Imaging Agents
  申请人：Perrin David

  公开号：US20100254903A1

  公开（公告）日：2010-10-07

  Substituted aryl-boron compounds comprising at least one 18 F atom, as illustrated by the formula (I), where at least one of Y 1 or Y 2 is 18 F and A 1 is a substituted aromatic ring, with G 1-5 being, independently, C or N, and where the substitutents of the aromatic ring or polycyclic moiety (other than boron) comprise at least one electron-withdrawing group (EWG), providing that sigma total (σ total ) for all substituents on the aromatic ring or polycyclic moiety except B is about 0.06 or more when said at least one EWG is positioned ortho to B, or about 0.2 or more when no EWG is positioned ortho to B. The compounds include neutral (N=1) and ionic borate (N=2) embodiments. The compounds are useful as positron emission tomography (PET) imaging agents.

  含有至少一个18F原子的取代芳基硼化合物，其由公式（I）所示，其中Y1或Y2中至少有一个为18F，A1为取代芳香环，G1-5分别为C或N，且芳香环或多环基团（除硼外）的取代基至少包括一个电子吸引基团（EWG），前提是当至少一个EWG位于B的正交位置时，芳香环或多环基团上所有取代基的总σ（σtotal）约为0.06或更高，或当没有EWG位于B的正交位置时，σtotal约为0.2或更高。该化合物包括中性（N=1）和离子硼酸盐（N=2）的实施例。该化合物可用作正电子发射断层扫描（PET）成像剂。
• US8574546B2
  申请人：——

  公开号：US8574546B2

  公开（公告）日：2013-11-05
• US9765075B2
  申请人：——

  公开号：US9765075B2

  公开（公告）日：2017-09-19