[2-[(3-硝基吡啶-2-基)氨基]苯基]-苯基甲酮 | 89153-91-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [2-[(3-硝基吡啶-2-基)氨基]苯基]-苯基甲酮
• 英文名称: [2-[(3-nitro-2-pyridinyl)amino]phenyl]phenylmethanone
• 英文别名: {2-[(3-Nitropyridin-2-yl)amino]phenyl}(phenyl)methanone；[2-[(3-nitropyridin-2-yl)amino]phenyl]-phenylmethanone
• CAS: 89153-91-3
• 化学式: C₁₈H₁₃N₃O₃
• 分子量: 319.32
• InChiKey: MRMOTKGMMJMALA-UHFFFAOYSA-N

物化性质

• 沸点：
  494.2±40.0 °C(Predicted)
• 密度：
  1.337±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [2-[(3-硝基吡啶-2-基)氨基]苯基]-苯基甲酮 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 [2-[(3-氨基吡啶-2-基)氨基]苯基]-苯基甲酮
  参考文献：
  名称：

  An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation

  摘要：

  An efficient synthesis of substituted 1,4-diazepines is developed. The accessible intermediates have been obtained via Pd-catalyzed amination. The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation. The mild and general strategy enables the synthesis of various substituted 1,4-diazepines in high yields. (C) 2013 Da-Li Yin. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.028
• 作为产物：
  描述：

  2-溴-3-硝基吡啶 、 2-氨基二苯甲酮 在 bis-triphenylphosphine-palladium(II) chloride 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 18.0h， 生成 [2-[(3-硝基吡啶-2-基)氨基]苯基]-苯基甲酮
  参考文献：
  名称：

  An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation

  摘要：

  An efficient synthesis of substituted 1,4-diazepines is developed. The accessible intermediates have been obtained via Pd-catalyzed amination. The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation. The mild and general strategy enables the synthesis of various substituted 1,4-diazepines in high yields. (C) 2013 Da-Li Yin. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.028

文献信息

• [2-[(Nitropyridinyl)amino]phenyl]arymethanones
  申请人：A. H. Robins Company, Inc.

  公开号：US04480100A1

  公开（公告）日：1984-10-30

  [2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: ##STR1## wherein: B is carbonyl, thioxomethyl, ketal or thioketal, R is hydrogen or -alk.sup.1 -Q, Q is hydrogen, --NR.sup.1 R.sup.2 or halogen are disclosed in a process for preparing pyrido[1,4]benzodiazepines.

  [2-[(硝基吡啶基)氨基]苯基]芳基甲酮作为化学中间体和/或具有抗抑郁活性，其化学式为：##STR1## 其中：B为羰基、硫代甲基、缩酮或硫代缩酮，R为氢或-烷基-Q，Q为氢、-NR^1R^2或卤素，在制备吡啶并[1,4]苯并二氮杂环己烷类化合物的过程中被揭示。
• [2-[(Nitropyridinyl)amino]phenyl]arylmethanones in a process for
  申请人：A. H. Robins Company, Inc.

  公开号：US04518603A1

  公开（公告）日：1985-05-21

  [2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: ##STR1## wherein; B is carbonyl, thioxomethyl, ketal or thioketal, R is hydrogen or --alk.sup.1 -Q, Q is hydrogen, --NR.sup.1 R.sup.2 or halogen are disclosed in a process for preparing pyrido[1,4]benzodiazepines.

  具有化学中间体和/或抗抑郁活性的[2-[(硝基吡啶基)氨基]苯基]芳基甲酮，其化学式为： ##STR1## 其中; B是羰基，硫代甲基，缩醛或硫缩缩醛，R是氢或--alk.sup.1 -Q，Q是氢，--NR.sup.1 R.sup.2或卤素，揭示了一种制备吡啶并[1,4]苯并二氮平的方法。
• LO, YOUNG, S.;TAYLOR, C. R. ,, JR.
  作者：LO, YOUNG, S.、TAYLOR, C. R. ,, JR.

  DOI：——

  日期：——
• LO, Y. S.;TAYLOR, C. R. ,, JR.
  作者：LO, Y. S.、TAYLOR, C. R. ,, JR.

  DOI：——

  日期：——
• (2-((Nitropyridinyl)amino)phenyl)arylmethanones and salts, their use in medicine, pharmaceutical compositions containing them and their use in the preparation of (2-((aminopyridinyl)amino)phenyl)arylmethanones and pyrido(1,4)benzodiazepines
  申请人：A.H. ROBINS COMPANY, INCORPORATED

  公开号：EP0107261B1

  公开（公告）日：1988-09-21