[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
• 化学式: C₂₄H₃₆O₅
• 分子量: 404.5
• InChiKey: DHNRPVXLKRMGGF-AWPUKBPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe
  申请人：KRKA, tovarna zdravil, d.d., Novo mesto

  公开号：EP2368543A1

  公开（公告）日：2011-09-28

  A method of preparing a granulated pharmaceutical composition by wet granulation, which method comprises: (a) suspending one or more pharmaceutically active ingredients comprising statin or ezetimibe or both statin and ezetimibe in a granulating liquid to form a granulating suspension; (b) optionally subjecting the granulating suspension of step (a) to high pressure homogenisation; (c) adding the granulating suspension of step (a) or (b) to a composition comprising one or more pharmaceutically acceptable inactive ingredients; and (d) granulating the mixture of step (c), as well as pharmaceutical compositions obtained by this process.

  一种通过湿法制粒制备颗粒药物组合物的方法，该方法包括(a) 将一种或多种包含他汀或依泽替米贝或他汀和依泽替米贝的药用活性成分悬浮于制粒液中，形成制粒悬浮液；(b) 可选择将步骤(a)的制粒悬浮液进行高压均质；(c) 将步骤(a)或(b)的制粒悬浮液加入包含一种或多种药学上可接受的非活性成分的组合物中；(d) 将步骤(c)的混合物以及通过该工艺获得的药物组合物制粒。