N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl)propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydron;chloride

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl)propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydron;chloride
• 化学式: C18H34Cl2N2O5S
• 分子量: 461.4
• InChiKey: AUODDLQVRAJAJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.81
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  128
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Antimicrobial compositions comprising minocycline and oxidized cellulose
  申请人：Omrix Biopharmaceuticals Ltd.

  公开号：US11000635B2

  公开（公告）日：2021-05-11

  Disclosed are compositions comprised of Oxidized Cellulose (OC), such as oxidized regenerated cellulose (ORC), and an antibiotic comprised of minocycline, methods of preparation thereof and uses thereof.

  公开了由氧化纤维素（OC）（如氧化再生纤维素（ORC））和米诺环素组成的抗生素组合物、其制备方法及其用途。
• Antimicrobial compositions comprising minocycline and degradation products of oxidized cellulose
  申请人：Omrix Biopharmaceuticals Ltd.

  公开号：US11045588B2

  公开（公告）日：2021-06-29

  Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.

  本文提供了一种由至少一种氧化纤维素（OC）降解产物（如氧化再生纤维素（ORC））和米诺环素组成的抗菌组合物、其制备方法及其用途。
• ANTIMICROBIAL COMPOSITIONS COMPRISING MINOCYCLINE AND OXIDIZED CELLULOSE
  申请人：Omrix Biopharmaceuticals Ltd.

  公开号：US20190184068A1

  公开（公告）日：2019-06-20

  Disclosed are compositions comprised of Oxidized Cellulose (OC), such as oxidized regenerated cellulose (ORC), and an antibiotic comprised of minocycline, methods of preparation thereof and uses thereof.
• ANTIMICROBIAL COMPOSITIONS COMPRISING MINOCYCLINE AND DEGRADATION PRODUCTS OF OXIDIZED CELLULOSE
  申请人：Omrix Biopharmaceuticals Ltd.

  公开号：US20190184069A1

  公开（公告）日：2019-06-20

  Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.
• TREATMENT FOR PROGRESSIVE MULTIPLE SCLEROSIS
  申请人：UTI LIMITED PARTNERSHIP

  公开号：US20190262353A1

  公开（公告）日：2019-08-29

  In one aspect, there is provided a method of treating, prophylaxis, or amelioration of a neurological disease by administering to a subject in need thereof one or more compounds described herein. In a specific example, the neurological disease is multiple sclerosis (also referred to as “MS”).