N-(4-Chloro-3-(trifluoromethyl)phenyl)-((4-(2-(N-methyl-carbamoyl)(4-pyridyloxy))phenyl)amino)

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(4-Chloro-3-(trifluoromethyl)phenyl)-((4-(2-(N-methyl-carbamoyl)(4-pyridyloxy))phenyl)amino)
• 英文别名: N-methyl-4-[4-[[4-methyl-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide
• 化学式: C₂₂H₁₉F₃N₄O₃
• 分子量: 444.4
• InChiKey: JXWBMSJTMHPJAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING<br/>[FR] ANTICORPS ANTI-VEGF ENTIÈREMENT HUMAINS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2009055343A2

  公开（公告）日：2009-04-30

  Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.