(5-Formylfuran-3-yl)methyl acetate | 919530-89-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-Formylfuran-3-yl)methyl acetate
• CAS: 919530-89-5
• 化学式: C₈H₈O₄
• 分子量: 168.15
• InChiKey: WUUUDNOHBDZGIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CONVERSION OF CARBOHYDRATES TO HYDROXYMETHYLFURFURAL (HMF) AND DERIVATIVES
  申请人：SANBORN Alexandra J.

  公开号：US20090156841A1

  公开（公告）日：2009-06-18

  A method of producing substantially pure HMF, HMF esters and other derivatives from a carbohydrate source by contacting the carbohydrate source with a solid phase catalyst. A carbohydrate starting material is heated in a solvent in a column and continuously flowed through a solid phase catalyst in the presence of an organic acid, or heated with the organic acid and a solid catalyst in solution to form a HMF ester. Heating without organic acid forms HMF. The resulting product is purified by filtration to remove the unreacted starting materials and catalyst. The HMF ester or a mixture of HMF and HMF ester may then be oxidized to 2,5-furandicarboxylic acid (FDCA) by combining the HMF ester with an organic acid, cobalt acetate, manganese acetate and sodium bromide under pressure. Alternatively, the HMF ester may be reduced to form a furan or tetrahydrofuran diol.

  一种从碳水化合物源直接生产几乎纯的HMF、HMF酯和其他衍生物的方法是将碳水化合物源与固相催化剂接触。碳水化合物起始物质在溶剂中加热于柱中，并在有机酸存在下通过固相催化剂连续流动，或者与有机酸和溶液中的固体催化剂一起加热以形成HMF酯。在无有机酸的情况下加热会形成HMF。通过过滤将产物纯化，去除未反应的起始物质和催化剂。然后，HMF酯或HMF和HMF酯的混合物可以氧化为2,5-呋喃二甲酸（FDCA），方法是将HMF酯与有机酸、醋酸钴、醋酸锰和溴化钠在压力下结合。另外，HMF酯可以还原形成呋喃或四氢呋喃二醇。
• Dopamine-beta-hydroxylase inhibitors
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0285356A2

  公开（公告）日：1988-10-05

  Compounds of formula (I) in which X is H, F, Cl, Br, I, C₁₋₄alkyl, CN, NO₂, SO₂NH₂, COOH, CHO, C₁₋₄alkoxy, CH₂OH, CF₃, SO₂CH₃, SO₂CF₃ or CO₂CaH2a+1 wherein a is 1-5, or any accessible combination thereof of up to 3 substituents; R is H or C₁₋₄alkyl; and n is 1-5; or any pharmaceutically acceptable salt or hydrate thereof, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as dopamine-β-hydroxylase inhibitors.

  式 (I) 的化合物 其中 X 是 H、F、Cl、Br、I、C₁₋₄alkyl、CN、NO₂、SO₂NH₂、COOH、CHO、C₁₋₄alkoxy、CH₂OH、CF₃、SO₂CH₃、SO₂CF₃ 或 CO₂CaH2a+1（其中 a 为 1-5），或其中最多 3 个取代基的任何可获得的组合；R 是 H 或 C₁₋₄ 烷基；或其任何药学上可接受的盐或水合物、其制备工艺、用于制备它们的中间体、含有它们的药物组合物以及它们作为多巴胺-β-羟化酶抑制剂在治疗中的用途。
• Conversion of carbohydrates to hydroxymethylfurfural (HMF) and derivatives
  申请人：Archer-Daniels-Midland Company

  公开号：EP2423205A1

  公开（公告）日：2012-02-29

  A method of producing substantially pure HMF, HMF esters and other derivatives from a carbohydrate source by contacting the carbohydrate source with a solid phase catalyst. A carbohydrate starting material is heated in a solvent in a column and continuously flowed through a solid phase catalyst in the presence of an organic acid, or heated with the organic acid and a solid catalyst in solution to form a HMF ester. Heating without organic acid forms HMF. The resulting product is purified by filtration to remove the unreacted starting materials and catalyst. The HMF ester or a mixture of HMF and HMF ester may then be oxidized to 2,5-furandicarboxylic acid (FDCA) by combining the HMF ester with an organic acid, cobalt acetate, manganese acetate and sodium bromide under pressure. Alternatively, the HMF ester may be reduced to form a furan or tetrahydrofuran diol.

  一种通过使碳水化合物源与固相催化剂接触，从碳水化合物源生产基本纯净的 HMF、HMF 酯和其他衍生物的方法。碳水化合物起始原料在柱中的溶剂中加热，并在有机酸存在下连续流过固相催化剂，或在溶液中与有机酸和固相催化剂一起加热以形成 HMF 酯。在不使用有机酸的情况下加热则会形成 HMF。所得产物通过过滤进行提纯，以除去未反应的起始原料和催化剂。然后，将 HMF 酯与有机酸、醋酸钴、醋酸锰和溴化钠加压混合，可将 HMF 酯或 HMF 和 HMF 酯的混合物氧化成 2,5-呋喃二甲酸（FDCA）。另一种方法是将 HMF 酯还原成呋喃或四氢呋喃二醇。
• OXIDATION OF A MIXTURE OF 2-HYDROXYMETHYL-5-FURFURALDEHYDE (HMF) AND AN ESTER THEREOF TO 2,5-FURANDICARBOXYLIC ACID (FDCA)
  申请人：Archer Daniels Midland Company

  公开号：EP2944632A1

  公开（公告）日：2015-11-18

  A method for oxidizing a reaction mixture of 2-hydroxymethyl-5-furfuraldehyde (HMF) and an ester of 2-hydroxymethyl-5-furfuraldehyde (HMF) to 2,5-furandicarboxylic acid (FDCA) by the addition of cobalt acetate, manganese acetate, sodium bromide under pressure and heat to form FDCA.

  一种在加压和加热条件下，通过加入醋酸钴、醋酸锰、溴化钠，将 2-羟甲基-5-糠醛（HMF）和 2-羟甲基-5-糠醛（HMF）的酯的反应混合物氧化成 2,5-呋喃二甲酸（FDCA），从而生成 FDCA 的方法。
• CONVERSION OF CARBOHYDRATES TO HYDROXY-METHYLFURFURAL (HMF) AND DERIVATIVES
  申请人：Archer Daniels Midland Company

  公开号：EP2217584A2

  公开（公告）日：2010-08-18