4-ethyl 1-methyl-1H pyrazole-5-amine | 354795-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-ethyl 1-methyl-1H pyrazole-5-amine
• 英文别名: 4-ethyl-2-methyl-2H-pyrazol-3-ylamine；4-Ethyl-1-methyl-1H-pyrazol-5-amine；4-ethyl-2-methylpyrazol-3-amine
• CAS: 354795-57-6
• 化学式: C₆H₁₁N₃
• mdl: MFCD14657261
• 分子量: 125.173
• InChiKey: XZBOXHMZSAQASG-UHFFFAOYSA-N

物化性质

• 沸点：
  251.0±20.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-ethyl 1-methyl-1H pyrazole-5-amine 、 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitrophenyl ester 以 二氯甲烷 为溶剂， 生成 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (4-ethyl-2-methyl-2H-pyrazol-3-yl)-amide
  参考文献：
  名称：

  Heterocyclic compounds and their therapeutic use

  摘要：

  其中R1是C1-3烷基，可选地被一个或多个氟原子取代；R2是C1-6烷基、环烷基或NR4R5；R3是部分公式（A）、（B）或（C）的吡唑、咪唑或异恶唑基团；NR4R5是含氮杂环；R6是C1-3烷基；R7和R8相同或不同，每个代表C1-3烷基、卤素、CF3或CN；或其药物可接受的盐。

  公开号：

  US06403791B1

文献信息

• HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
  申请人：Chuaqui Claudio

  公开号：US20120040951A1

  公开（公告）日：2012-02-16

  The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

  本发明提供了式（I）的化合物，可用作Raf蛋白激酶的抑制剂。本发明还提供了其组合物以及治疗Raf介导疾病的方法。
• Bicyclic aza compounds as muscarinic M1 receptor and/or M4 receptor agonists
  申请人：Heptares Therapeutics Limited

  公开号：US10196380B2

  公开（公告）日：2019-02-05

  This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1, R2, R3 and R4 are as defined herein.

  本发明涉及的化合物是毒蕈碱 M1 受体和/或 M4 受体的激动剂，可用于治疗毒蕈碱 M1/M4 受体介导的疾病。本发明还提供了含有这些化合物的药物组合物以及这些化合物的治疗用途。化合物包括根据式 1 的化合物或其盐，其中 Q、R1、R2、R3 和 R4 如本文所定义。
• Bicyclic aza compounds as muscarnic M1 receptor and/or M4 receptor antagonists
  申请人：Heptares Therapeutics Limited

  公开号：US10385039B2

  公开（公告）日：2019-08-20

  This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof wherein Q, R1, R2, R3 and R4 are as defined herein.

  本发明涉及的化合物是毒蕈碱 M1 受体和/或 M4 受体的激动剂，可用于治疗毒蕈碱 M1/M4 受体介导的疾病。本发明还提供了含有这些化合物的药物组合物以及这些化合物的治疗用途。化合物包括根据式 1 的化合物或其盐，其中 Q、R1、R2、R3 和 R4 如本文所定义。
• Bicyclic aza compounds as muscarinic M1 receptor and/or M4 receptor
  申请人：Heptares Therapeutics Limited

  公开号：US10689368B2

  公开（公告）日：2020-06-23

  This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1, R2, R3 and R4 are as defined herein.

  本发明涉及的化合物是毒蕈碱 M1 受体和/或 M4 受体的激动剂，可用于治疗毒蕈碱 M1/M4 受体介导的疾病。本发明还提供了含有这些化合物的药物组合物以及这些化合物的治疗用途。化合物包括根据式 1 的化合物或其盐，其中 Q、R1、R2、R3 和 R4 如本文所定义。
• Bicyclic AZA compounds as muscarinic M1 receptor and/or M4 receptor
  申请人：Heptares Therapeutics Limited

  公开号：US10961225B2

  公开（公告）日：2021-03-30

  This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1, R2, R3 and R4 are as defined herein.

  本发明涉及的化合物是毒蕈碱 M1 受体和/或 M4 受体的激动剂，可用于治疗毒蕈碱 M1/M4 受体介导的疾病。本发明还提供了含有这些化合物的药物组合物以及这些化合物的治疗用途。化合物包括根据式 1 的化合物或其盐，其中 Q、R1、R2、R3 和 R4 如本文所定义。