α-Amino-4-hydroxy-propiophenon | 7146-65-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-Amino-4-hydroxy-propiophenon
• 英文别名: 2-amino-1-(4-hydroxy-phenyl)-propan-1-one; hydrochloride；2-Amino-1-(4-hydroxy-phenyl)-propan-1-on; Hydrochlorid；2-Amino-1-(4-hydroxyphenyl)propan-1-one hydrochloride；2-amino-1-(4-hydroxyphenyl)propan-1-one;hydrochloride
• CAS: 7146-65-8
• 化学式: C₉H₁₁NO₂*ClH
• 分子量: 201.653
• InChiKey: QSJIZQZNPCLCJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.34
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  potassium cyanate 、 α-Amino-4-hydroxy-propiophenon 在 水 作用下， 生成 4-(4-hydroxy-phenyl)-5-methyl-1,3-dihydro-imidazol-2-one
  参考文献：
  名称：

  US2514380

  摘要：

  公开号：

文献信息

• Synthesis and uses of synephrine derivatives
  申请人：Chen Jian

  公开号：US20050250944A1

  公开（公告）日：2005-11-10

  The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β 3 -adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.

  本发明公开了一种新型合成橙皮碱、其衍生物和上述衍生物的盐，包括它们的中间体。橙皮碱的氮原子的一个或多个取代基被修改以产生衍生物。橙皮碱衍生物及其盐可用于治疗受β3-肾上腺素受体调节的动物的疾病、症状或紊乱。它们通常用作脂肪分解剂和/或减肥剂。
• Process for the production of optically active beta-amino alcohols
  申请人：——

  公开号：US20040091981A1

  公开（公告）日：2004-05-13

  A process for producing an optical active &bgr;-amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to the genus Morganella and others, to act on an enantiomeric mixture of an &agr;-aminoketone or a salt thereof having the general formula (I): 1 to produce an optical active &bgr;-amino alcohol with the desired optical activity having the general formula (II) described below in a high yield as well as in a highly selective manner: 2

  一种制备光学活性&bgr;-氨基醇的方法，包括以下步骤：让至少一种选择自属于摩根氏菌属和其他微生物组的微生物作用于具有通式(I)的&agr;-氨基酮或其盐的对映异构体混合物，以高产率和高选择性地产生具有所需光学活性的&bgr;-氨基醇，其通式为(II)：
• PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS
  申请人：Daiichi Fine Chemical Co., Ltd.

  公开号：EP1273665A1

  公开（公告）日：2003-01-08

  A process for producing an optical active β-amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to the genus Morganella and others, to act on an enantiomeric mixture of an α-aminoketone or a salt thereof having the general formula (I): to produce an optical active β-amino alcohol with the desired optical activity having the general formula (II) described below in a high yield as well as in a highly selective manner:

  一种生产光学活性 β-氨基醇的方法，该方法包括以下步骤：让至少一种选自摩根菌属微生物及其他微生物组成的微生物作用于具有通式（I）的α-氨基酮或其盐的对映体混合物： 以高产率和高选择性的方式生产出具有所需光学活性的 β-氨基醇，其通式（II）如下所述：
• US2514380
  申请人：——

  公开号：——

  公开（公告）日：——
• US6835559B2
  申请人：——

  公开号：US6835559B2

  公开（公告）日：2004-12-28