[4-(3,4-二氯苯基)-2-(4-甲氧基苯基)噻唑-5-基]-(1,1,3,3-四甲基丁基)胺 | 1041436-36-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: [4-(3,4-二氯苯基)-2-(4-甲氧基苯基)噻唑-5-基]-(1,1,3,3-四甲基丁基)胺
• 英文名称: [4-(3,4-dichlorophenyl)-2-(4-methoxyphenyl)thiazol-5-yl]-(1,1,3,3-tetramethylbutyl)amine
• 英文别名: 4-(3,4-dichlorophenyl)-2-(4-methoxyphenyl)-N-(2,4,4-trimethylpentan-2-yl)-1,3-thiazol-5-amine
• CAS: 1041436-36-5
• 化学式: C₂₄H₂₈Cl₂N₂OS
• 分子量: 463.471
• InChiKey: NXWVTDLSAAPZHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  62.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [4-(3,4-二氯苯基)-2-(4-甲氧基苯基)噻唑-5-基]-(1,1,3,3-四甲基丁基)胺 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以47%的产率得到4-(3,4-dichlorophenyl)-2-(4-methoxyphenyl)thiazol-5-ylamine
  参考文献：
  名称：

  Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling

  摘要：

  A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction, in the presence of Lawesson's reagent. The Walborsky reagent ( 1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N-alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.06.067
• 作为产物：
  描述：

  N-(1-(3,4-dichlorophenyl)-2-oxo-2-(2,4,4-trimethylpentan-2-ylamino)ethyl)-4-methoxybenzamide 在 劳森试剂 作用下， 以 间二甲苯 为溶剂， 反应 3.0h， 以36%的产率得到[4-(3,4-二氯苯基)-2-(4-甲氧基苯基)噻唑-5-基]-(1,1,3,3-四甲基丁基)胺
  参考文献：
  名称：

  Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling

  摘要：

  A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction, in the presence of Lawesson's reagent. The Walborsky reagent ( 1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N-alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.06.067

文献信息

• [EN] THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS<br/>[FR] DÉRIVÉS DE THIAZOLE ET D'OXAZOLE S'UTILISANT DANS LE TRAITEMENT DE MALADIES À PRIONS, DU CANCER ET DE TROUBLES DU SYSTÈME NERVEUX CENTRAL, ET DANS LA RÉGULATION DE CELLULES SOUCHES
  申请人：UNIV SHEFFIELD

  公开号：WO2008090382A1

  公开（公告）日：2008-07-31

  [EN] Compounds of the formula (I) are provided: Fomula (I) wherein X, Y, R1, R2 and R3 are as defined in the specification. The compounds may be useful in the treatment of various diseases and conditions, in particular prion diseases.
  [FR] L'invention concerne des composés représentés par la formule (I), dans laquelle X, Y, R1, R2 et R3 sont tels que définis dans la description. Ces composés peuvent être utiles dans le traitement de diverses maladies et affections, en particulier les maladies à prions.
• Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling
  作者：Mark J. Thompson、Beining Chen

  DOI：10.1016/j.tetlet.2008.06.067

  日期：2008.9

  A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction, in the presence of Lawesson's reagent. The Walborsky reagent ( 1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N-alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions. (C) 2008 Elsevier Ltd. All rights reserved.