Monomethyl Auristatin F

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Monomethyl Auristatin F
• 英文别名: 2-[[3-methoxy-3-[1-[3-methoxy-5-methyl-4-[methyl-[3-methyl-2-[[3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid
• 化学式: C₃₉H₆₅N₅O₈
• 分子量: 732.0
• InChiKey: MFRNYXJJRJQHNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  52
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  167
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• SITE-SPECIFIC LABELING METHODS AND MOLECULES PRODUCED THEREBY
  申请人：GEIERSTANGER Bernhard Hubert

  公开号：US20170218085A1

  公开（公告）日：2017-08-03

  The present invention provides methods of site-specific labeling of antibodies, using proteins having 4′-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates.