3-Deoxyglycerogalacto-2-nonulopyranosonic acid | 22594-61-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Deoxyglycerogalacto-2-nonulopyranosonic acid
• 英文别名: (4S,5R,6R,7R,8S)-4,5,6,7,8,9-hexahydroxy-2-oxononanoic acid
• CAS: 22594-61-2
• 化学式: C₉H₁₆O₉
• 分子量: 268.22
• InChiKey: FQHUAUMYHAJTDH-IMSDGWMTSA-N

物化性质

• 熔点：
  154-162 °C
• 沸点：
  679.7±55.0 °C(Predicted)
• 密度：
  1.722±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  176
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• Arrays with cleavable linkers
  申请人：Wong Chi-Huey

  公开号：US20070213278A1

  公开（公告）日：2007-09-13

  The invention provides arrays of molecules where the molecules (e.g., glycans) are attached to the arrays by cleavable linkers. The invention also provides methods for using these arrays, methods for identifying the structural elements of molecules bound to these arrays by using the cleavable linkers, especially the structural elements that are important for binding to test samples. The invention further provides methods for evaluating whether test samples and test molecules can bind to distinct glycans on the arrays and useful glycans identified using the methods and arrays provided herein.

  本发明提供了分子阵列，其中分子（例如糖基）通过可断裂连接剂连接到阵列上。本发明还提供了使用这些阵列的方法，使用可断裂连接剂识别结合到这些阵列上的分子的结构元素的方法，特别是对于与测试样品结合重要的结构元素。本发明还提供了评估测试样品和测试分子是否能够结合到阵列上不同糖基的方法，以及使用本发明提供的方法和阵列确定的有用糖基。
• METHOD FOR SPECIFICALLY LABELING LIVING BACTERIA
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：US20140363817A1

  公开（公告）日：2014-12-11

  The present invention concerns a method for labeling specifically living bacteria of a given category in a sample, the method including: a) incubating said bacteria of said sample with at least one analog of a monosaccharide compound, and b) contacting the bacteria with a labeling molecule having a second reactive group.

  本发明涉及一种用于在样品中特异性标记给定类别的活菌的方法，该方法包括：a）将所述样品中的所述菌株与至少一种单糖化合物的类似物一起孵育，并b）将该菌株与具有第二反应性基团的标记分子接触。
• A method for specifically detecting living bacteria
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP2617833A1

  公开（公告）日：2013-07-24

  The present invention concerns a method for detecting specifically living bacteria of a given category of bacteria in a sample comprising bacteria, the method comprising the steps of: a) incubating said bacteria of said sample with an analog of a monosaccharide compound, said monosaccharide being an endogenous monosaccharide residue of glycans of the outer membrane of such given category of bacteria, the said endogenous monosaccharide residue comprising an ulosonic acid or ulosonate salt residue, the said analog of a monosaccharide compound being a modified monosaccharide substituted at a given position by a first reactive chemical group capable to react with a second reactive group of a detectable molecule, and b) contacting said bacteria with a said detectable molecule comprising a said second reactive group, for generating the reaction of said first reactive group of said analog residue incorporated within said glycans of the outer membrane of said bacteria with said second reactive group of said detectable, and c) detecting whether said bacteria comprise said detectable molecule bound to the glycans of their outer membrane.

  本发明涉及一种在包含细菌的样品中检测特定类别细菌的方法，该方法包括以下步骤： a) 用单糖化合物类似物培养所述样品中的所述细菌，所述单糖是该类细菌外膜糖的内源性单糖残基、所述内源性单糖残基包括一个溃疡酸或溃疡酸盐残基，所述单糖化合物类似物是在给定位置被能够与可检测分子的第二活性基团反应的第一活性化学基团取代的改性单糖，以及 b) 将所述细菌与包含所述第二活性基团的所述可检测分子接触，以产生包含在所述细菌外膜聚糖中的所述类似残基的所述第一活性基团与所述可检测分子的所述第二活性基团的反应，以及 c) 检测所述细菌的外膜聚糖上是否包含所述可检测分子。
• RAPID AND ACCURATE ANALYSIS OF PROTEIN SIALYLATION
  申请人：Grifols, S.A.

  公开号：EP2733218A1

  公开（公告）日：2014-05-21

  The invention relates to methods and kits for the analysis of the sialylation of gluco-proteins. The samples of gluco-protein are incubated separately under three conditions: with beta-galactosidase, with beta-galactosidase + alpha-sialidase, and without an enzyme. After the enzyme treatment, high performance anion exchange chromatography with pulsed amperometric detection (HPAEC PAD) is used to make a quantitative determination of the total galactose in the sample, the non sialylated galactose and the exogenous galactose in the medium. The determination of said values makes it possible to deduce the percentage of sialylation of the gluco-protein.

  本发明涉及分析葡萄糖蛋白的糖基化的方法和试剂盒。葡萄糖蛋白样品在三种条件下分别孵育：与β-半乳糖苷酶、与β-半乳糖苷酶+α-硅糖苷酶和不加酶。酶处理后，使用带脉冲安培检测（HPAEC PAD）的高效阴离子交换色谱法对样品中的总半乳糖、非硅烷基化半乳糖和培养基中的外源半乳糖进行定量测定。通过上述数值的测定，可以推断出葡萄糖蛋白的糖基化百分比。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。