2-((R)-1-tert-Butoxycarbonylamino-3-phenyl-propyl)-oxazole-4-carboxylic acid methyl ester | 233690-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-((R)-1-tert-Butoxycarbonylamino-3-phenyl-propyl)-oxazole-4-carboxylic acid methyl ester
• 英文别名: methyl 2-[(1R)-1-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropyl]-1,3-oxazole-4-carboxylate
• CAS: 233690-45-4
• 化学式: C₁₉H₂₄N₂O₅
• 分子量: 360.41
• InChiKey: FDQIPQGIABIEQM-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  90.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-((R)-1-tert-Butoxycarbonylamino-3-phenyl-propyl)-oxazole-4-carboxylic acid methyl ester 在 potassium carbonate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 2-[(R)-1-((R)-2,5-Diamino-pentanoylamino)-3-phenyl-propyl]-oxazole-4-carboxylic acid naphthalen-2-ylamide; compound with trifluoro-acetic acid
  参考文献：
  名称：

  Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

  摘要：

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00006-9
• 作为产物：
  描述：

  (S)-2-((R)-2-tert-Butoxycarbonylamino-4-phenyl-butyrylamino)-3-hydroxy-propionic acid methyl ester 在 伯吉斯试剂 、 乌洛托品 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 copper(ll) bromide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2-((R)-1-tert-Butoxycarbonylamino-3-phenyl-propyl)-oxazole-4-carboxylic acid methyl ester
  参考文献：
  名称：

  Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

  摘要：

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00006-9

文献信息

• US6204279B1
  申请人：——

  公开号：US6204279B1

  公开（公告）日：2001-03-20
• US6436980B1
  申请人：——

  公开号：US6436980B1

  公开（公告）日：2002-08-20
• Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa
  作者：Thomas E. Renau、Roger Léger、Rose Yen、Miles W. She、Eric M. Flamme、Joan Sangalang、Carla L. Gannon、Suzanne Chamberland、Olga Lomovskaya、Ving J. Lee

  DOI：10.1016/s0960-894x(02)00006-9

  日期：2002.3

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.