ethyl 3-(6-methoxy-3-methyl-1H-indol-2-yl)propionate | 519158-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 3-(6-methoxy-3-methyl-1H-indol-2-yl)propionate
• 英文别名: ethyl 3-(6-methoxy-3-methyl-1H-indol-2-yl)propanoate
• CAS: 519158-41-9
• 化学式: C₁₅H₁₉NO₃
• 分子量: 261.321
• InChiKey: VSNSWOQIJYRXJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl 3-(6-methoxy-3-methyl-1H-indol-2-yl)acrylate 在 10% palladium on activated carbon 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.83h， 生成 ethyl 3-(6-methoxy-3-methyl-1H-indol-2-yl)propionate
  参考文献：
  名称：

  BICYCLIC COMPOUND

  摘要：

  公开号：

  EP1447400B1

文献信息

• Bicyclic compound
  申请人：Miyoshi Shiro

  公开号：US20050020602A1

  公开（公告）日：2005-01-27

  A compound represented by the general formula I: I wherein R1 represents hydrogen, etc. R 2 represents NHSO 2 R 3 , etc., provided that R 3 represents C 1-6 alkyl, etc. R 5 represents hydrogen, etc. R 6 and R 7 may be the same or different and each independently represents hydrogen, etc. X represents oxygen, etc. Y represents oxygen, etc. Z 1 to Z 6 each represents carbon, etc. n is an integer of 0 to 6 and ast1 indicates that the carbon atom is asymmetric, and *2, in the case where R 5 is not hydrogen, indicates that the carbon atom is asymmetric or a salt of the compound.

  化合物的通式为I：I，其中R1代表氢等，R2代表NHSO2R3等，但R3代表C1-6烷基等，R5代表氢等，R6和R7可以相同也可以不同，且各自独立地代表氢等，X代表氧等，Y代表氧等，Z1至Z6各自代表碳等，n为0至6的整数，ast1表示碳原子是不对称的，*2表示当R5不是氢时，碳原子是不对称的或化合物的盐。
• Indole compounds as B3 androceptor agonist
  申请人：Miyoshi Shiro

  公开号：US20080076815A1

  公开（公告）日：2008-03-27

  Compounds of the general formula (I): or a salt thereof, wherein R 1 is a hydrogen atom or the like; R 2 is NHSO 2 R 3 or the like; R 3 is a (C 1 -C 6 )alkyl group or the like; R 5 is a hydrogen atom or the like; R 6 and R 7 may be the same or different and are each independently a hydrogen atom or the like; X is an oxygen atom or the like; Y is an oxygen atom or the like; Z 1 to Z 6 are a carbon atom or the like; n is an integer of 0 to 6; *1 is an asymmetric carbon atom; and *2 is an asymmetric carbon atom when R 5 is other than a hydrogen atom.

  通式(I)的化合物或其盐，其中R1是氢原子或类似物；R2是NHSO2R3或类似物；R3是(C1-C6)烷基或类似物；R5是氢原子或类似物；R6和R7可以相同或不同，且各自独立地是氢原子或类似物；X是氧原子或类似物；Y是氧原子或类似物；Z1至Z6是碳原子或类似物；n是0到6的整数；*1是不对称碳原子；当R5不是氢原子时，*2是不对称碳原子。
• INDOLE COMPOUNDS AS BETA3 ANDROCEPTOR AGONIST
  申请人：Miyoshi Shiro

  公开号：US20080015242A1

  公开（公告）日：2008-01-17

  Compounds of the general formula (I): or a salt thereof, wherein R 1 is a hydrogen atom or the like; R 2 is NHSO 2 R 3 or the like; R 3 is a (C 1 -C 6 )alkyl group or the like; R 5 is a hydrogen atom or the like; R 6 and R 7 may be the same or different and are each independently a hydrogen atom or the like; X is an oxygen atom or the like; Y is an oxygen atom or the like; Z 1 to Z 6 are a carbon atom or the like; n is an integer of 0 to 6; *1 is an asymmetric carbon atom; and *2 is an asymmetric carbon atom when R 5 is other than a hydrogen atom.

  通式（I）的化合物或其盐，其中R1是氢原子或类似物；R2是NHSO2R3或类似物；R3是（C1-C6）烷基或类似物；R5是氢原子或类似物；R6和R7可以相同也可以不同，分别是氢原子或类似物；X是氧原子或类似物；Y是氧原子或类似物；Z1到Z6是碳原子或类似物；n是0到6的整数；*1是不对称碳原子；当R5不是氢原子时，*2是不对称碳原子。
• Bicyclic compounds
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1935882A1

  公开（公告）日：2008-06-25

  Compounds of the general formula (I): or a salt thereof, wherein R1 is a hydrogen atom or the like; R2 is NHSO2R3 or the like; R3 is a (C1-C6)alkyl group or the like; R5 is a hydrogen atom or the like; R6 and R7 may be the same or different and each independently represents a hydrogen atom or the like; X is an oxygen atom or the like; Y is an oxygen atom or the like; Z1 to Z6 are a carbon atom or the like; n is an integer of 0 to 6; * 1 is an asymmetric carbon atom; and *2 is an asymmetric carbon atom when R5 is other than a hydrogen atom.

  通式 (I) 的化合物： 或其盐，其中 R1 是氢原子或类似物；R2 是 NHSO2R3 或类似物；R3 是(C1-C6)烷基或类似物；R5 是氢原子或类似物；R6 和 R7 可以相同或不同，且各自独立地代表氢原子或类似物；X 是氧原子或类似物；Y 是氧原子或类似物；Z1 至 Z6 是碳原子或类似物；n 是 0 至 6 的整数；*1 是不对称碳原子；当 R5 不是氢原子时，*2 是不对称碳原子。
• US7271190B2
  申请人：——

  公开号：US7271190B2

  公开（公告）日：2007-09-18