[5-（4-氯苯基）-2-噻吩基]甲胺盐酸盐 | 1166853-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [5-（4-氯苯基）-2-噻吩基]甲胺盐酸盐
• 英文名称: (5-(4-chlorophenyl)thiophen-2-yl)methaneamine hydrochloride
• 英文别名: 2-(Aminomethyl)-5-(4-Chlorophenyl)Thiophene Hydrochloride；[5-(4-chlorophenyl)thiophen-2-yl]methanamine;hydrochloride
• CAS: 1166853-02-6
• 化学式: C₁₁H₁₀ClNS*ClH
• 分子量: 260.187
• InChiKey: OGIWIXDYSIQBDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  54.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  [5-（4-氯苯基）-2-噻吩基]甲胺盐酸盐 、 在 sodium cyanoborohydride 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以46%的产率得到
  参考文献：
  名称：

  Glycosylated glycopeptide antibiotic derivatives

  摘要：

  本发明提供了一种新型的糖肽抗生素衍生物，包括一个由公式表示的糖残基(I)：（其中n为1至5的整数，Sugs分别独立地表示单糖，(Sug)n表示由1至5个相同或不同的单糖结合形成的二价糖残基；RA1为可选的取代较低烷基、可选的取代较低烯基或可选的取代环烷基；RE为OH或NHAc（Ac为乙酰基）），与糖肽骨架中第四个氨基酸残基的芳香环结合。这些衍生物具有抗耐万古霉素细菌的活性。

  公开号：

  US08481696B2

文献信息

• GLYCOSYLATED GLYCOPEPTIDE ANTIBIOTIC DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：EP2233495A1

  公开（公告）日：2010-09-29

  The present invention provides novel glycopeptides antibiotic derivatives. These glycopeptide antibiotic derivatives are characterized in that a sugar residue (I) represented by the formula: (wherein n is an integer of 1 to 5; Sugs are each independently a monosaccharide, (Sug)n is a divalent sugar residue formed by binding of same or different 1 to 5 monosaccharides; RA1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, or optionally substituted cycloalkyl; and RE is OH or NHAc (Ac is acetyl)) is bound to an aromatic ring of the fourth amino acid residue in the glycopeptide skeleton. These derivatives have antibacterial activity against vancomycin-resistant bacteria.

  本发明提供了新型糖肽抗生素衍生物。 这些糖肽抗生素衍生物的特征在于由式（I）代表的糖残基： (其中n是1至5的整数；Sugs各自独立地是单糖，(Sug)n是由相同或不同的1至5单糖结合形成的二价糖残基；RA1是任选取代的低级烷基、任选取代的低级烯基或任选取代的环烷基；RE是OH或NHAc(Ac是乙酰基)) 与糖肽骨架中第四个氨基酸残基的芳香环结合。 这些衍生物对耐万古霉素细菌具有抗菌活性。
• GLYCOSYLATED GLYCOPEPTIDE ANTIBIOTIC DERIVATIVES
  申请人：Matsui Kouhei

  公开号：US20100286364A1

  公开（公告）日：2010-11-11

  The present invention provides novel glycopeptides antibiotic derivatives. These glycopeptide antibiotic derivatives are characterized in that a sugar residue (I) represented by the formula: (wherein n is an integer of 1 to 5; Sugs are each independently a monosaccharide, (Sug) n is a divalent sugar residue formed by binding of same or different 1 to 5 monosaccharides; R A1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, or optionally substituted cycloalkyl; and R E is OH or NHAc (Ac is acetyl)) is bound to an aromatic ring of the fourth amino acid residue in the glycopeptide skeleton. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
• US8481696B2
  申请人：——

  公开号：US8481696B2

  公开（公告）日：2013-07-09
• Glycosylated glycopeptide antibiotic derivatives
  申请人：Matsui Kouhei

  公开号：US08481696B2

  公开（公告）日：2013-07-09

  The present invention provides novel glycopeptides antibiotic derivatives comprising a sugar residue (I) represented by the formula: (wherein n is an integer of 1 to 5: Sugs are each independently a monosaccharide, (Sug)n is a divalent sugar residue formed by binding of same or different 1 to 5 monosaccharides; RA1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, or optionally substituted cycloalkyl; and RE is OH or NHAc (Ac is acetyl)) is bound to an aromatic ring of the fourth amino acid residue in the glycopeptide skeleton. These derivatives have antibacterial activity against vancomycin-resistant bacteria.

  本发明提供了一种新型的糖肽抗生素衍生物，包括一个由公式表示的糖残基(I)：（其中n为1至5的整数，Sugs分别独立地表示单糖，(Sug)n表示由1至5个相同或不同的单糖结合形成的二价糖残基；RA1为可选的取代较低烷基、可选的取代较低烯基或可选的取代环烷基；RE为OH或NHAc（Ac为乙酰基）），与糖肽骨架中第四个氨基酸残基的芳香环结合。这些衍生物具有抗耐万古霉素细菌的活性。