N-(1,2-benzoxazol-3-yl)-2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxoacetamide | 501921-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(1,2-benzoxazol-3-yl)-2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxoacetamide
• CAS: 501921-79-5
• 化学式: C₂₄H₁₆ClN₃O₃
• 分子量: 429.862
• InChiKey: CNRATIYZPRKKDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,2-苯并异恶唑-3-胺 、 2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxoacetyl chloride 在 TEA 作用下， 以 四氢呋喃 为溶剂， 生成 N-(1,2-benzoxazol-3-yl)-2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxoacetamide
  参考文献：
  名称：

  Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines

  摘要：

  We report herein the SAR studies of a series of indole- and indolizine-glyoxylamides that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance ( MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins ( e. g., breast, colon, uterine). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.029

文献信息

• Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines
  作者：David A. James、Keizo Koya、Hao Li、Guiqing Liang、Zhiqiang Xia、Weiwen Ying、Yaming Wu、Lijun Sun

  DOI：10.1016/j.bmcl.2008.02.029

  日期：2008.3

  We report herein the SAR studies of a series of indole- and indolizine-glyoxylamides that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance ( MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins ( e. g., breast, colon, uterine). (C) 2008 Elsevier Ltd. All rights reserved.