(3R,9R,10R)-9-hydroxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.02,10.03,7.015,19]icosa-1(20),7,13,15(19)-tetraen-12-one

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 石蒜科生物碱
• 英文名称: (3R,9R,10R)-9-hydroxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.02,10.03,7.015,19]icosa-1(20),7,13,15(19)-tetraen-12-one
• 化学式: C₁₇H₁₇NO₅
• 分子量: 315.32
• InChiKey: DGQPIOQRPAGNGB-IXFHYDNRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  68.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Methods for inhibiting muscle atrophy
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US11090313B2

  公开（公告）日：2021-08-17

  The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).

  本发明提供了一种方法，用于(a)增加骨骼肌质量；(b)减少骨骼肌萎缩；(c)增加肌肉力量；(d)促进肌肉生长；(e)减少肌肉萎缩；或(f)在确定或已确定需要(a)-(f)中的一项或多项的动物中增加单位肌肉质量的力量，该方法包括向动物施用有效量的式化合物： 或其立体异构体、溶液或药学上可接受的盐，从而实现(a)-(f)中的一项或多项。
• METHODS FOR INHIBITING MUSCLE ATROPHY
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US20200061083A1

  公开（公告）日：2020-02-27

  The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).