(2R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (2R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 化学式: C₁₀H₁₃N₅O₄
• 分子量: 267.24
• InChiKey: OIRDTQYFTABQOQ-PKJMTWSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF
  申请人：Shi Jiangong

  公开号：US20130045942A1

  公开（公告）日：2013-02-21

  The present invention provides N 6 -substituted adenosine derivatives and N 6 -substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

  本发明提供了N6-取代腺苷衍生物和N6-取代腺嘌呤衍生物，其制备方法，包括上述化合物的药物组合物，以及这些化合物在制造治疗失眠、惊厥、癫痫和帕金森病的药物和保健产品以及预防和治疗痴呆症中的用途。
• METHOD FOR TREATING INFLAMMATORY CONDITIONS
  申请人：Douglass, III James G.

  公开号：US20100160250A1

  公开（公告）日：2010-06-24

  This invention provides a method for inhibiting the release of interleukin-1β in a mammal. This invention also provides a method for preventing or treating pulmonary diseases, ophthalmic diseases, and autoimmune diseases that are associated with inflammation or inflammatory conditions. The invention also provides a method for preventing or treating neurodegenerative diseases, or pain in a mammal. The method comprises administering to a mammal in need thereof a therapeutically effective amount of a mononucleoside compound, which is an antagonist of P2X 7 receptor.

  这项发明提供了一种抑制哺乳动物体内白细胞介素-1β释放的方法。该发明还提供了一种预防或治疗与炎症或炎症性疾病相关的肺部疾病、眼科疾病和自身免疫疾病的方法。该发明还提供了一种预防或治疗哺乳动物体内神经退行性疾病或疼痛的方法。该方法包括向需要的哺乳动物体内施用一种单核苷酸化合物的治疗有效剂量，该化合物是P2X7受体的拮抗剂。
• Se-Adenosyl-L-Selenohomocysteine Selenoxide As A Modulator Of Methyltransferase And Other Activities
  申请人：Northeastern University

  公开号：US20160090397A1

  公开（公告）日：2016-03-31

  The invention relates to a compound of the structural formula or a hydrate or an isotope thereof. The invention also relates to a preparation method thereof and methods of providing dietary organoselenium, inactivating an enzyme, modulating the activity of a protein (e.g., methyltransferase) or nucleic acid, identifying a methyltransferase that reacts with compound, and oxidizing a methyltransferase-reactive substrate.

  本发明涉及一种结构式为或其水合物或同位素的化合物。本发明还涉及其制备方法以及提供膳食有机硒，失活酶，调节蛋白质（例如甲基转移酶）或核酸活性的方法，识别与化合物反应的甲基转移酶，以及氧化甲基转移酶反应底物的方法。
• METHOD OF TREATING INFLAMMATION
  申请人：Brubaker Kurt E.

  公开号：US20070249556A1

  公开（公告）日：2007-10-25

  This invention provides methods of preventing and/or treating diseases or conditions associated with inflammation in a mammal, particularly a human. The method comprises administering to a mammal in need thereof an effective amount of a compound of Formula I, IA, or IB, wherein said amount is effective to inhibit inflammation. The invention also provides methods for inhibiting chemotaxis of leukocytes.

  本发明提供了一种预防和/或治疗与哺乳动物（特别是人类）炎症相关的疾病或病症的方法。该方法包括向需要的哺乳动物投与公式I、IA或IB化合物的有效量，其中该量足以抑制炎症。本发明还提供了抑制白细胞趋化的方法。
• NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
  申请人：QUART Barry D.

  公开号：US20090197825A1

  公开（公告）日：2009-08-06

  Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

  本文描述了一些有用的化合物，可以调节血尿酸水平，包含它们的制剂和使用它们的方法。在某些实施例中，所述的化合物用于治疗或预防与尿酸异常水平相关的疾病。