[R-(Z)]-12-羟基-N,N-二(2-羟基乙基)-9-十八碳烯酰胺 | 40716-42-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: [R-(Z)]-12-羟基-N,N-二(2-羟基乙基)-9-十八碳烯酰胺
• 中文别名: 蓖麻醇酸酰胺DEA
• 英文名称: N,N-bis(2-hydroxyethyl)ricinoleamide
• 英文别名: 9-Octadecenamide, 12-hydroxy-N,N-bis(2-hydroxyethyl)-, (9Z,12R)-；(Z,12R)-12-hydroxy-N,N-bis(2-hydroxyethyl)octadec-9-enamide
• CAS: 40716-42-5
• 化学式: C₂₂H₄₃NO₄
• 分子量: 385.588
• InChiKey: PDVQCPFKYPYROG-ZDKIGPTLSA-N

物化性质

• 沸点：
  560.5±50.0 °C(Predicted)
• 密度：
  1.007±0.06 g/cm3(Predicted)
• LogP：
  4.867 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [R-(Z)]-12-羟基-N,N-二(2-羟基乙基)-9-十八碳烯酰胺 在 双氧水 、 溶剂黄146 作用下， 以 环己烷 为溶剂， 生成
  参考文献：
  名称：

  CN116969855

  摘要：

  公开号：
• 作为产物：
  描述：

  蓖麻油酸 、 二乙醇胺 以 甲苯 为溶剂， 生成 [R-(Z)]-12-羟基-N,N-二(2-羟基乙基)-9-十八碳烯酰胺
  参考文献：
  名称：

  CN116969855

  摘要：

  公开号：

文献信息

• Microbubble formation using ultrasound
  申请人：——

  公开号：US20030032879A1

  公开（公告）日：2003-02-13

  Disclosed herein are agents for enhancing the contrast in a diagnostic ultrasound procedure. These agents comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase has a boiling point at or below the body temperature of the organism to be studied and thus undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to an organism. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.

  本文公开了一种增强诊断超声成像对比度的药剂。这些药剂包括液体-液体型胶体分散液，即乳液或微乳液，其中分散液相在被检测生物体的体温以下沸点，因此在给生物体注射后从分散液体相转变为高声学对比度的分散气态泡沫或库格尔沙。分散相的液态使得可以制造粒径通常低于1000纳米的极其稳定的药用乳剂。体温下的气态产生高声学对比度的微泡，直径通常低于10,000纳米，有效作为超声对比剂。描述了静脉、动脉内、口服、腹腔内和子宫内剂量形式、给药方法和成像技术。
• Compositions and methods for directed ultrasound imaging
  申请人：SONUS PHARMACEUTICALS, INC.

  公开号：EP0727225A2

  公开（公告）日：1996-08-21

  Compositions for enhancing the ability to target gaseous microbubbles used in ultrasound contrast. The compositions include a cell adhesion molecule (CAM) ligand which is incorporated into a desired molecule to form a conjugate. Where the contrast agent is a collidal dispersion, the conjugate is formed with a surfactant. Where the agent is a solid microsphere, the conjugate is formed with the a portion of the solid. Once the conjugate is formed, the surfactant or microsphere will adhere to the surface of desired target cells by coupling of the CAM ligand to cell adhesion molecules expressed on the cell surface.

  用于提高超声造影中气态微泡靶向能力的组合物。这些组合物包括一种细胞粘附分子（CAM）配体，将其与所需分子结合形成共轭物。如果造影剂是胶体分散体，则与表面活性剂形成共轭物。如果造影剂是固体微球，则与固体的一部分形成共轭物。一旦共轭物形成，表面活性剂或微球将通过 CAM 配体与细胞表面表达的细胞粘附分子的偶联作用，粘附到所需的靶细胞表面。
• Preparation method for shear-thinning water-based ball-point pen inks, shear-thinning water-based ball-point pen ink compositions, and ball-point pens employing the same
  申请人：The Pilot Ink CO., Ltd.

  公开号：EP0787779A2

  公开（公告）日：1997-08-06

  A shear-thinning water-based ball-point pen ink composition comprising from 1% by weight to 35% by weight of a colorant, from 2% by weight to 35% by weight of a water-soluble polar solvent, from 1% by weight to 30% by weight of a nonionic surface active agent having an HLB value within the range of from 8 to 12, and the balance being water and adjusting additives, and having a viscosity within the range of from 25 mPa.s to 160 mPa.s (a value at the number of revolution of 100 rpm in an EM type rotational viscometer, 25°C) and a shear thinning index within the range of from 0.1 to 0.6; the nonionic surface active agent having a mixed phase comprising a phase standing dispersed in the form of fine particles and a phase standing dissolved in a molecular state. A method for preparing the ink composition and a ball-point pen employing the ink composition are also disclosed.

  一种剪切稀化型水基圆珠笔墨水组合物，包括重量百分比为 1%至 35%的着色剂、重量百分比为 2%至 35%的水溶性极性溶剂、重量百分比为 1%至 30%的 HLB 值在 8 至 12 范围内的非离子表面活性剂，余量为水和调节添加剂。s至 160 mPa.s（在 EM 型旋转粘度计中，转速为 100 rpm，温度为 25℃时的值），剪切稀化指数在 0.1 至 0.6 之间；非离子表面活性剂具有混合相，混合相包括以细颗粒形式分散的相和以分子状态溶解的相。 此外，还公开了制备该墨水组合物的方法和使用该墨水组合物的圆珠笔。
• One-Pot Synthesis of Ricinoleic Acid Diethanolamide Triglycidyl Ether
  作者：H. Zhang、J. Wu、F. Zhu、X. Zhang、X. Zhu

  DOI：10.1007/s10600-019-02646-2

  日期：2019.1
• Synthesis and Characterization of Ricinoleamide-Based Polyurethane
  作者：Mohammad Kashif、Eram Sharmin、Fahmina Zafar、Sharif Ahmad

  DOI：10.1007/s11746-011-1867-z

  日期：2011.12

  AbstractRicinus communis (RC) oil‐based materials are currently receiving increasing attention because of economic and environmental concerns. In the present work, RC oil—a natural triol has been utilized for the development of an advanced polymeric material—poly(urethane‐ricinoleamide) (PUR) through very simple synthesis and curing strategy, omitting derivatization steps or side reactions, chain extenders and crosslinkers. The synthesis of PUR was carried out in two steps. The first step is the introduction of an amide group in the RC oil (89.5% ricinoleic acid) via base catalyzed amidation, which results in N, N‐bis (2‐hydroxyethyl) ricinoleamide (HERA). The second step is urethanation of HERA by the reaction of toluene‐2,4‐diisocyanate (TDI) in minimal possible organic solvent by one‐shot technique, which results in the formation of polyurethane along with amide linkages. The physico‐chemical and spectral studies (FT‐IR, 1H‐NMR and 13C‐NMR techniques) confirm these two reactions and the structure of PUR. The resin was cured at ambient temperature without any cross linker. Solubility of the resin was investigated in different polar and non‐polar solvents. Thermo‐gravimetric analysis (TGA)/differential thermal analysis (DTA) and Differential Scanning Calorimetry (DSC) were used to determine the thermal stability and curing behavior of PUR. An ambient cured ricinoleamide modified polyurethane resin exhibited thermal resistance up to 200–220 °C.