1,1-Dimethyl-e-ethyl-2-acetyl-cyclobutan | 4951-97-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-Dimethyl-e-ethyl-2-acetyl-cyclobutan
• 英文别名: 1-(3-Ethyl-2,2-dimethylcyclobutyl)ethanone
• CAS: 4951-97-7
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: XNOFWVNVNSRMKB-UHFFFAOYSA-N

物化性质

• 沸点：
  237.64°C (rough estimate)
• 密度：
  0.8704 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] C-3 NOVEL TRITERPENONE WITH C-28 UREA DERIVATIVES AS HIV INHIBITORS<br/>[FR] NOUVELLE TRITERPÉNONE EN C-3 AVEC DES DÉRIVÉS D'URÉE EN C-28 EN TANT QU'INHIBITEURS DE VIH
  申请人：HETERO RESEARCH FOUNDATION

  公开号：WO2017064628A1

  公开（公告）日：2017-04-20

  The present invention relates to C-3 novel triterpenone with C-28 urea derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, W, J and X are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) useful for the treatment of viral diseases and particularly HIV mediated diseases.

  本发明涉及具有式(I)的C-28脲衍生物的C-3新型三萜酮；或药学上可接受的盐、药学上可接受的溶剂化合物、药学上可接受的水合物、互变异构体、立体异构体、前药、组合物或其组合，其中R1、R2、R3、W、J和X如本文所定义。本发明还涉及包含式(I)化合物的药物组合物，用于治疗病毒性疾病，特别是HIV介导的疾病。
• Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
  申请人：Hendrix A. James

  公开号：US20070142351A1

  公开（公告）日：2007-06-21

  The invention relates to heterocyclic substituted amide derivatives that display selective binding to dopamine D 3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D 3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D 3 receptors.

  本发明涉及杂环取代酰胺衍生物，其显示对多巴胺D3受体的选择性结合。另一方面，本发明涉及一种治疗中枢神经系统疾病的方法，该疾病与需要该治疗的患者的多巴胺D3受体活性有关，包括向受试者投予所述化合物的治疗有效量以缓解该疾病。这些化合物可以治疗的中枢神经系统疾病包括精神病性障碍、物质依赖、物质滥用、运动障碍（如帕金森病、帕金森综合征、神经阻滞剂引起的迟发性运动障碍、吉尔·德·拉·图雷特综合征和亨廷顿病）、痴呆、焦虑症、睡眠障碍、昼夜节律障碍和情绪障碍。本发明还涉及制备上述化合物的过程，以及将这些化合物用作多巴胺D3受体成像剂的方法。
• SUBSTITUTED DIMETHYLCYCLOBUTYL COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
  申请人：Laboratorios del Dr. Esteve, S.A.

  公开号：EP2066648B1

  公开（公告）日：2017-04-12
• Fragrance compositions from tertiary terpene alcohols
  申请人：Kane J. Bernard

  公开号：US20070238629A1

  公开（公告）日：2007-10-11

  Cyclic ethers or chloroketones useful as fragrance components or intermediates are made by reacting a saturated, tertiary terpene alcohol with hypochloric acid under conditions effective to promote oxidation. trans-Pinanol gives predominantly 6,9-dimethyl-7-oxatricyclo[4.3.0.0 3.9 ]-nonane, while cis-pinanol yields almost exclusively 1-acetyl-3-(2-chloroethyl)-2,2-dimethylcyclobutane, a new and versatile intermediate for making cyclobutane derivatives having interesting and diverse aromas.
• US7560598B2
  申请人：——

  公开号：US7560598B2

  公开（公告）日：2009-07-14