1-[4-[[(4-Methylphenyl)sulfonyl]oxy][1,1a(2)-biphenyl]-3-yl]ethanone | 1000171-07-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-[[(4-Methylphenyl)sulfonyl]oxy][1,1a(2)-biphenyl]-3-yl]ethanone
• 英文别名: (2-acetyl-4-phenylphenyl) 4-methylbenzenesulfonate
• CAS: 1000171-07-2
• 化学式: C₂₁H₁₈O₄S
• 分子量: 366.438
• InChiKey: GXNMBDLNNSJZPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2-Acetyl-4-chlorophenyl) 4-methylbenzenesulfonate 、 苯基三氟硼酸钾 在 palladium diacetate 三乙胺 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以71%的产率得到1-[4-[[(4-Methylphenyl)sulfonyl]oxy][1,1a(2)-biphenyl]-3-yl]ethanone
  参考文献：
  名称：

  Palladium-Catalyzed Suzuki−Miyaura Cross-Couplings of Aryl Tosylates with Potassium Aryltrifluoroborates

  摘要：

  [Graphics]Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl tosylates with potassium aryl trifluoroborate in the presence of bulky and electron-rich phosphine ligand is described. In addition, a useful chemoselective coupling of an aryl chloride in the presence of a tosyloxy group was demonstrated.

  DOI：

  10.1021/jo7019064

文献信息

• Palladium-Catalyzed Suzuki−Miyaura Cross-Couplings of Aryl Tosylates with Potassium Aryltrifluoroborates
  作者：Liang Zhang、Tianhao Meng、Jie Wu

  DOI：10.1021/jo7019064

  日期：2007.11.1

  [Graphics]Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl tosylates with potassium aryl trifluoroborate in the presence of bulky and electron-rich phosphine ligand is described. In addition, a useful chemoselective coupling of an aryl chloride in the presence of a tosyloxy group was demonstrated.