streptomycin | 11011-72-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: streptomycin
• 英文别名: bluensomycin；[(1R,2S,3S,4R,5R,6R)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl] carbamate
• CAS: 11011-72-6
• 化学式: C₂₁H₃₉N₅O₁₄
• 分子量: 585.566
• InChiKey: RQLDKUSQKQMFCN-AEXVNIBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.3
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  328
• 氢给体数：
  12
• 氢受体数：
  16

文献信息

• [EN] ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE<br/>[FR] CONJUGUÉS ANIONIQUES D'UN MÉTABOLITE BACTÉRIEN GLYCOSYLÉ
  申请人：GLYCAN BIOSCIENCES PTY LTD

  公开号：WO2010037179A1

  公开（公告）日：2010-04-08

  The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

  该发明涉及与糖基化细菌代谢产物的阴离子结合物，可用于模拟被称为糖胺聚糖（GAGs）的阴离子生物活性分子的结构和/或活性。该发明还涉及制备这些结合物的过程。这些结合物在预防和/或治疗疾病条件方面具有用处，特别是慢性疾病条件，如炎症（包括过敏）疾病、转移性癌症和感染病原体（包括细菌、病毒或寄生虫）的情况。
• Aminoglycoside-polyamine displacers and methods of use in displacement chromatography
  申请人：Rege Kaushal

  公开号：US20070049741A1

  公开（公告）日：2007-03-01

  Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R 1 is an alkyl group or an azaalkyl group, and R 2 is a primary or secondary amino group.

  本文披露了氨基糖苷-多胺以及它们在置换色谱和作为DNA结合配体中的使用方法。氨基糖苷-多胺是碳水化合物的衍生物，例如糖，氨基糖，去氧糖，糖苷，核苷和它们的取代物。这些多胺具有取代至少一种碳水化合物化合物的至少一个羟基的氨基团。在这些化合物中，R1是烷基或氮杂基，R2是一级或二级氨基。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• AMINOGLYCOSIDE DOSING REGIMENS
  申请人：Bruss Jon B.

  公开号：US20120208781A1

  公开（公告）日：2012-08-16

  The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.

  本发明提供了新的氨基糖苷类药物给药方案，与增强微生物杀灭活性和降低肾毒性有关，并提供了使用这些给药方案治疗各种细菌感染的方法。
• Cloning vectors for use in Streptomyces
  申请人：ELI LILLY AND COMPANY

  公开号：EP0077649A2

  公开（公告）日：1983-04-27

  The present invention discloses selectable recombinant DNA cloning vectors comprising: a) a functional origin of replication containing restriction fragment of plasmid pEL103, and b) one or more DNA segments that convey resistance to at least one antibiotic when transformed into a sensitive host cell, said host cell being susceptible to transformation, cell division, and culture, for use in Streptomyces and related organisms.

  本发明公开了可选择的重组 DNA 克隆载体，该载体包括：a) 含有质粒 pEL103 限制性片段的功能性复制起源；b) 一个或多个 DNA 片段，当其转化到敏感的宿主细胞中时，可传递对至少一种抗生素的抗性，所述宿主细胞易于转化、细胞分裂和培养，用于链霉菌和相关生物。