alpha-[2-(二乙基氨基)乙基]二苯甲醇 | 4369-48-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: alpha-[2-(二乙基氨基)乙基]二苯甲醇
• 英文名称: 1,1-Diphenyl-3-diethylamino-propanol-(1)
• 英文别名: 1-Propanol, 3-(diethylamino)-1,1-diphenyl-；3-(diethylamino)-1,1-diphenylpropan-1-ol
• CAS: 4369-48-6
• 化学式: C₁₉H₂₅NO
• 分子量: 283.414
• InChiKey: FUZZXFCCNFATNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  alpha-[2-(二乙基氨基)乙基]二苯甲醇 在 氯化亚砜 、 氯仿 作用下， 生成 diethyl-(3-chloro-3,3-diphenyl-propyl)-amine
  参考文献：
  名称：

  Kawabata; Nitta; Kasai, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1949, vol. 69, p. 190

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯甲酮 、 N,N-二乙基氯乙胺 在 1,2-diphenyl-1,2-disodiumethane 、 水 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 以58%的产率得到alpha-[2-(二乙基氨基)乙基]二苯甲醇
  参考文献：
  名称：

  Tuning the Reducing Properties of 1,2-Diaryl-1,2-disodiumethanes

  摘要：

  We investigated the reducing properties of a series of 1,2-diaryl-1,2-disodiumethanes by means of equilibration reactions. The electron-donor power of these vic-diorganometals is strongly affected by the nature of substituents present either on the aromatic ring(s) or on the carbanionic centers, and it can be correlated with their ability to delocalize the arylmethyl carbanions. These findings are supported by electrochemical analysis of the reduction behavior of the parent 1,2-diarylalkene. Applications of these results to the reduction of selected substrates are described.

  DOI：

  10.1021/jo901183x

文献信息

• Studies on Application of Amino Acid as Medicinal Agent. I. Syntheses of Amino-tert-alcohol Derivatives
  作者：SEIGORO HAYASHI、MITSURU FURUKAWA、YOKO FUJINO、NAOTO MATSUISHI、TADASHI OHKAWARA

  DOI：10.1248/cpb.17.145

  日期：——

  In order to find non-narcotic analgesics, 54 compounds of amino-tert-alcohol, in which a variety of substituent groups were involved at the carbon atom in 1-position and at the amino group, were synthesized by reacting various α-and β-amino acid esters with Grignard reagents. These amino acid esters were readily reacted with alkyl Grignard reagents to give the expected compounds. However, when bulky aromatic Grignard reagents were submitted to react, the reactions were found to stop at the stage of intermediate formation of the corresponding ketones.

  为了寻找非麻醉性镇痛药，通过将各种α-和β-氨基酸酯与格氏试剂反应，合成了54种氨基叔醇化合物，这些化合物在1-位碳原子和氨基上涉及多种取代基团。这些氨基酸酯容易与烷基格氏试剂反应，得到预期的化合物。然而，当使用庞大的芳香族格氏试剂进行反应时，发现反应停止在相应的酮中间体形成阶段。
• Adamson et al., Journal of the Chemical Society, 1949, p. Spl. 144, 152
  作者：Adamson et al.

  DOI：——

  日期：——
• DE875660
  申请人：——

  公开号：——

  公开（公告）日：——
• Adamson et al., Journal of the Chemical Society, 1951, p. 52,58
  作者：Adamson et al.

  DOI：——

  日期：——
• Coyle,S. et al., Journal of the Chemical Society. Perkin transactions I, 1979, p. 1459 - 1463
  作者：Coyle,S. et al.

  DOI：——

  日期：——