5-[5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclopentyltetrazole | 1016556-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclopentyltetrazole
• CAS: 1016556-39-0
• 化学式: C₂₂H₁₉Cl₃N₆
• 分子量: 473.792
• InChiKey: ZIZNSQZNQXDTMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  溴代环己烷 、 5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-1H-tetrazole 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以61%的产率得到5-[5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclopentyltetrazole
  参考文献：
  名称：

  Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists

  摘要：

  Cannabinoid CB1 receptors have been the focus of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed a new series of tetrazole-biarylpyrazoles. The various analogues were efficiently prepared and bioassayed for binding to cannabinoid CB1 receptor. Six of the new compounds which displayed high in vitro CB1 binding affinities were assayed for binding to CB2 receptor. Noticeably, cyclopentyl-tetrazole (9a) demonstrated good binding affinity and selectivity for CB1 receptor (IC50 = 11.6 nM and CB2/CB1 = 366). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.061

文献信息

• Heteroaryl-Pyrazole Derivatives as Cannabinoid CB1 Receptor Antagonists
  申请人：LEE Jinhwa

  公开号：US20080081812A1

  公开（公告）日：2008-04-03

  A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB 1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The present invention also provides a method for preparing the inventive heteroaryl-pyrasole compounds or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.

  一种异芳基-吡唑化合物，其公式为(I)或其药用可接受盐，可作为大麻素CB1受体的反向激动剂或拮抗剂，用于预防或治疗肥胖及其相关代谢紊乱。本发明还提供了制备本发明的异芳基-吡唑化合物或其药用可接受盐的方法，包含该化合物的药物组合物，以及用于预防或治疗肥胖及其相关代谢紊乱的方法。
• Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists
  申请人：Lee Jinhwa

  公开号：US20080081815A1

  公开（公告）日：2008-04-03

  A novel heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB 1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The prevention also provide a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.

  化合物I式的新型杂环基吡唑化合物或其药学上可接受的盐，作为大麻素CB1受体的反向激动剂或拮抗剂，对于预防或治疗肥胖症和肥胖相关代谢紊乱是有效的。该预防还提供了一种制备方法、包含该化合物的制药组合物以及预防或治疗肥胖症和肥胖相关代谢紊乱的方法。
• HETEROARYL-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS
  申请人：Green Cross Corporation

  公开号：EP2097410A1

  公开（公告）日：2009-09-09
• US7875647B2
  申请人：——

  公开号：US7875647B2

  公开（公告）日：2011-01-25
• [EN] HETEROARYL-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS D'HÉTÉROARYL-PYRAZOLE UTILISÉS EN TANT QU'ANTAGONISTES DU RÉCEPTEUR CB1 DES CANNABINOÏDES
  申请人：GREEN CROSS CORP

  公开号：WO2008039023A1

  公开（公告）日：2008-04-03

  [EN] A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The present invention also provides a method for preparing the inventive heteroaryl-pyrasole compounds or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.
  [FR] L'invention concerne un composé d'hétéroaryl-pyrazole représenté par la formule (I) ou un sel pharmaceutiquement acceptable de ce dernier efficace en tant qu'agoniste inverse ou antagoniste du récepteur CB1 des cannabinoïdes, qui est utile pour prévenir ou traiter l'obésité et les troubles métaboliques liés à l'obésité. La présente invention concerne également une méthode de préparation des composés d'hétéroaryl-pyrazole selon l'invention ou d'un sel pharmaceutiquement acceptable de ces derniers, une composition pharmaceutique les contenant, ainsi qu'une méthode de prévention ou de traitement de l'obésité et de troubles métaboliques liés à l'obésité.