N-[(2R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(2R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• 化学式: C₈H₁₅NO₆
• 分子量: 221.21
• InChiKey: OVRNDRQMDRJTHS-WTZNIHQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  6

ADMET

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时进行治疗……监测休克，并在必要时进行治疗……预计癫痫发作，并在必要时进行治疗……对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于摄入，如果患者能吞咽，有强烈的呕吐反射，并且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……在去污后，用干燥的消毒敷料覆盖皮肤烧伤……/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。开始静脉输液，使用D5W（5%葡萄糖溶液）/SRP: "保持开放"，最低流量/。如果出现低血容量的迹象，使用乳酸钠林格液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压，谨慎输液。注意液体过载的迹象。使用地西泮（安定）治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。/毒药A和B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

/其他毒性信息/ 几丁质在结构上与活性成分壳聚糖（多聚-D-葡萄糖胺）非常相似，壳聚糖对哺乳动物没有毒性，并且已被美国食品药品监督管理局（FDA）批准作为食品添加剂。

/OTHER TOXICITY INFORMATION/ Chitin is closely related structurally to the active ingredient chitosan (poly-D-glucosamine), which shows no toxicity to mammals, and is approved by FDA as a food additive.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：急性暴露/在毒性测试中，唯一观察到的影响是在壳聚糖涂抹于皮肤后出现的轻微皮肤刺激。/壳聚糖/

/LABORATORY ANIMALS: Acute Exposure/ In toxicity tests, the only effect seen was slight skin irritation after chitosan was applied to skin. /Chitosan/

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• US5767256A
  申请人：——

  公开号：US5767256A

  公开（公告）日：1998-06-16
• [EN] SOLUTION AND SOLID PHASE STEREOCONTROLLED GLYCOSIDATION<br/>[FR] GLYCOSIDATION STEREOREGULEE EN PHASE SOLIDE ET EN SOLUTION
  申请人：——

  公开号：WO1995003316A2

  公开（公告）日：1995-02-02

  [EN] Novel glycosides containing novel leaving groups, pyridyloxy, pyrimidyloxy, methoxypyridyloxy, pyridyl carbonate and pyridyl thiocarbonate are utilized in many fertile syntheses of glycosides, disaccharides, trisaccharides, oligosaccharides, nucleosides and the like. These synthetic schemes are superior in stereospecificity, yield and speed of preparation of numerous novel compounds. Polymer supported syntheses may be utilized within the general scheme to provide enhanced product purity.
  [FR] De nouveaux glycosides, contenant de nouveaux groupes partants pyridyloxy, pyrimidyloxy, méthoxypyridyloxy, carbonate pyridilyque et thiocarbonate pyridylique sont utilisés dans de nombreuses synthèses fertiles de glycosides, de disaccharides, de trisaccharides, d'oligosaccharides, de nucléosides et l'équivalent. Avec ces schémas synthétiques, il est possible d'obtenir une stéréospécificité, un rendement et une vitesse de préparation supérieurs pour de nombreux nouveaux composés. Des synthèses à support polymère peuvent être utilisées dans le schéma général de manière à obtenir un produit de pureté accrue.
• [EN] OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION<br/>[FR] CONJUGUÉS LIGANDS D'OLIGONUCLÉOTIDES ET PROCÉDÉ POUR LEUR PRÉPARATION
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2015006740A2

  公开（公告）日：2015-01-15

  The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.