(1R,2S,3S,4S,6R)-4-amino-6-(methoxymethyl)cyclohexane-1,2,3-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,2S,3S,4S,6R)-4-amino-6-(methoxymethyl)cyclohexane-1,2,3-triol
• 化学式: C₈H₁₇NO₄
• 分子量: 191.22
• InChiKey: HCWFZBZMZQPEIZ-OMKQZNDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.9
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] RAPAMYCIN CARBOHYDRATE DERIVATIVES<br/>[FR] DERIVES DE RAPAMYCINE CARBOHYDRATE
  申请人：ISOTECHNIKA INTERNAT INC

  公开号：WO2004101583A1

  公开（公告）日：2004-11-25

  This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.

  这项发明提供了经过改良的雷帕霉素，其具有通过连接剂连接的特定单糖，寡糖，伪糖或其衍生物，从而创造出具有增强药代动力学和/或药效动力学特性的雷帕霉素糖衍生物。例如，给予雷帕霉素糖衍生物的治疗导致了改变的药代动力学特性和降低的毒性。因此，本发明提供了具有与其他同类药物（如雷帕霉素）不同特性的化合物。
• Modulators of Hypoxia Inducible Factor-1 and Related Uses
  申请人：Gardiner Gregory

  公开号：US20090023666A1

  公开（公告）日：2009-01-22

  The invention features compounds of formulas I or II: and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.

  这项发明涉及公式I或II的化合物：以及这些化合物的药用盐和前药，以及使用这些化合物调节局部和全身缺氧事件效应的方法。
• [EN] ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE<br/>[FR] CONJUGUÉS ANIONIQUES D'UN MÉTABOLITE BACTÉRIEN GLYCOSYLÉ
  申请人：GLYCAN BIOSCIENCES PTY LTD

  公开号：WO2010037179A1

  公开（公告）日：2010-04-08

  The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

  该发明涉及与糖基化细菌代谢产物的阴离子结合物，可用于模拟被称为糖胺聚糖（GAGs）的阴离子生物活性分子的结构和/或活性。该发明还涉及制备这些结合物的过程。这些结合物在预防和/或治疗疾病条件方面具有用处，特别是慢性疾病条件，如炎症（包括过敏）疾病、转移性癌症和感染病原体（包括细菌、病毒或寄生虫）的情况。
• HYPOGLYCEMIC EFFECT ENHANCER
  申请人：Isa Yasuhiro

  公开号：US20120014923A1

  公开（公告）日：2012-01-19

  A hypoglycemic effect enhancer for enhancing the activity of an α-glucosidase inhibitor, the enhancer comprising at least one kind of bacteria selected from the group consisting of bifidobacteria, lactic acid bacteria, saccharifying bacteria, and butyric acid bacteria.

  一种降血糖作用增强剂，用于增强α-葡萄糖苷酶抑制剂的活性，该增强剂包括从双歧杆菌、乳酸菌、糖化细菌和丁酸菌组成的细菌中至少一种。
• [EN] ENASIDENIB GLYCOSIDES AND METHODS OF TREATING DISEASES ASSOCIATED WITH ISOCITRATE DEHYDROGENASE (IDH) DYSFUNCTION<br/>[FR] GLYCOSIDES D'ENASIDENIB ET PROCÉDÉS DE TRAITEMENT DE MALADIES ASSOCIÉES À UN DYSFONCTIONNEMENT DE L'ISOCITRATE DÉSHYDROGÉNASE (IDH)
  申请人：DOUBLERAINBOW BIOSCIENCES INC

  公开号：WO2021188456A1

  公开（公告）日：2021-09-23

  Enasidenib glycosides and methods of making enasidenib glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to enasidenib to yield enasidenib glycosides. Suitable monosaccharides can be in the L- or D- configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, galacturonate, glucose, glucuronic acid, mannose, N-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.

  本文介绍了Enasidenib糖苷及其制备方法。糖基转移酶催化将一个或多个单糖添加到Enasidenib中，形成Enasidenib糖苷。适宜的单糖可以是L-或D-构型，并且通常具有5、6或7个碳。适宜的单糖包括阿洛糖、芹糖、阿拉伯糖、果糖、甘露醇、岩藻糖、半乳糖、半乳糖醛酸酯、葡萄糖、葡萄糖醛酸、甘露糖、N-乙酰葡萄糖胺、鼠李糖或木糖。尿苷二磷酸糖基转移酶可以催化α或β糖苷键的形成。