Dimethyl maleic aldehyde

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Dimethyl maleic aldehyde
• 英文别名: (Z)-2,3-dimethylbut-2-enedial
• 化学式: C₆H₈O₂
• 分子量: 112.13
• InChiKey: DYZREBHDZOIXCW-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] CRYSTALLINE FORM OF QUINAPRIL HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME<br/>[FR] FORME CRISTALLINE D'UN HYDROCHLORURE DE QUINAPRIL ET PROCEDE DE PREPARATION DE CELLE-CI
  申请人：LUPIN LTD

  公开号：WO2004054980A1

  公开（公告）日：2004-07-01

  A novel crystalline form of quinapril hydrochloride of formula (I). An amorphous form of quinapril hydrochloride substantially free of impurities, specially diketopiperazine compound, and conforming to pharmacopoeial specifications formed from the said novel crystalline form of quinapril hydrochloride of formula (I). The crystalline quinapril hydrochloride is in the form nitroalkane solvate in which the nitroalkane is nitromethane, nitroethane and nitropropane. Each such nitroalkane solvate having particular characteristic X- ray diffraction patterns. A process for preparation of amorphous from of quinapril hydrochloride, substantially free of impurities, specially diketopiperazine compound, and conforming to pharmacopoeial specifications, using the novel crystalline quinapril hydrochloride as an intermediate. The process involves obtaining free base compound of formula (V) by adjusting the pH of a solution of the benzyl ester maleate salt of quinapril of formula (V) between 7.5-8.5 in a mixture of water and an organic solvent; catalytic hydrogenation of this compound (V) in an alcoholic solvent in the presence of concentrated hydrochloric acid or hydrogen chloride dissolved in an alcoholic solvent and in the presence of catalytic amounts of Pd/C to obtain a residue containing formula (I); crystallization of the said residue by evaporating the alcoholic solvent from a nitroalkane solvent to give crystalline quinapril hydrochloride, associated with a solvate of the nitroalkane solvent, and drying the crystalline quinapril hydrochloride nitroalkane solvate at a temperature between 40°C and 45°C under vacuum to give amorphous quinapril hydrochloride of formula (I).

  盐酸喹那普利的一种新颖结晶形式，其化学式为(I)。一种基本上无杂质的盐酸喹那普利无定形形式，特别是二酮哌嗪化合物，并且符合药典规格，由所述的盐酸喹那普利新颖结晶形式（化学式为I）形成。该结晶形式的盐酸喹那普利是以硝基烷为溶剂的溶剂化物，其中硝基烷是硝基甲烷、硝基乙烷和硝基丙烷。每一种这样的硝基烷溶剂化物都具有特定的特征X-射线衍射图谱。一种制备基本上无杂质，特别是二酮哌嗪化合物，并符合药典规格的盐酸喹那普利无定形形式的过程，使用新颖的结晶盐酸喹那普利作为中间体。该过程包括通过将喹那普利苯甲基酯马来酸盐（化学式为V）的水和有机溶剂混合溶液的pH值调整在7.5-8.5之间，获得自由碱化合物（化学式为V）；在醇溶剂中对该化合物（V）进行催化氢化，在浓盐酸或溶于醇溶剂中的氯化氢的存在下，以及在Pd/C的催化量存在下，获得含有化学式（I）的残留物；通过从硝基烷溶剂中蒸发醇溶剂使所述残留物结晶，得到与硝基烷溶剂的溶剂化物相关的结晶盐酸喹那普利，并在40°C至45°C的温度下，在真空下干燥结晶盐酸喹那普利硝基烷溶剂化物，得到无定形的盐酸喹那普利（化学式为I）。
• N-Phenyl-maleinimide und N-Phenyl-succinimide mit herbizider und pflanzenwuchsregulierender Wirkung
  申请人：CIBA-GEIGY AG

  公开号：EP0260228A2

  公开（公告）日：1988-03-16

  Neue Derivate des N-Phenylmaleinsäureimides und des N-Phenylsuccinimides der untenstehenden Formel haben gute pre- und postemergente selektiv-herbizide Eigenschaften und sie beeinflussen das Pflanzenwachstum. Die Verbindungen entsprechen der Formel I worin I : für eine Einfach- oder Doppelbindung, R1 für Wasserstoff und Fluor, R2 für Halogen, Y für C1-C8-Alkyl, Z für Wasserstoff oder C1-C8-Alkyl, und A für Wasserstoff oder eine Gruppe stehen, wobei R3, R4, R5, R6, R7 und R8 übliche organische Reste und X Sauerstoff, Schwefel, SO, S02, NH, Alkylimino oder Alkenylimino bedeuten.

  下式中的 N-苯基马来酰亚胺和 N-苯基琥珀酰亚胺的新衍生物具有良好的苗前和苗后选择性除草特性，并能影响植物生长。这些化合物符合式 I 式中 I ：代表单键或双键、 R1 代表氢和氟、 R2 代表卤素 Y 为 C1-C8 烷基 Z 代表氢或 C1-C8 烷基，以及 A 代表氢或一个基团 基团、 其中 R3、R4、R5、R6、R7 和 R8 为常规有机基，X 为氧、硫、SO、S02、NH、烷基亚氨基或烯基 亚氨基。
• N-SUBSTITUTED 2,5-DIOXO-AZOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
  申请人：CanBas Co., Ltd.

  公开号：EP3567035A1

  公开（公告）日：2019-11-13

  Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

  本发明提供了新型取代唑二酮类化合物，可杀死细胞、抑制细胞增殖、抑制细胞生长、减弱细胞周期 G2 检查点和/或导致细胞周期 G2 停滞。本发明还提供了制造和使用本发明化合物的方法。本发明提供了用于治疗细胞增殖障碍的取代唑二酮类化合物。本发明包括使用取代的唑二酮选择性地杀死或抑制癌细胞，而无需额外的抗癌治疗。本发明包括使用细胞周期G2-检查点抑制取代的唑二酮类化合物选择性地使癌细胞对DNA损伤试剂、治疗和/或其它类型的抗癌试剂敏感。
• COMPOUNDS THAT ABROGATE THE CELL CYCLE G2 CHECKPOINT FOR USE IN THE TREATMENT OF CANCER
  申请人：CanBas Co., Ltd.

  公开号：EP3088397B1

  公开（公告）日：2019-04-10
• NOVEL ADDUCT COMPOUND, METHODS FOR PURIFICATION AND PREPARATION OF FUSED POLYCYCLIC AROMATIC COMPOUND, SOLUTION FOR FORMATION OF ORGANIC SEMICONDUCTOR FILM, AND NOVEL ALPHA-DIKETONE COMPOUND
  申请人：Ikeda Yoshinori

  公开号：US20120211731A1

  公开（公告）日：2012-08-23

  Provided are a novel adduct compound and a novel α-diketone compound, from which organic semiconductor layers consisting of a fused polycyclic aromatic compound can be formed by a solution method, said solution method being generally easier than a deposition method. Also provided are a method for the purification of the adduct compound, and a solution for the formation of organic semiconductor film, which contains the adduct compound. The adduct compound has a structure wherein a compound having a double bond is added in an eliminable state to a fused polycyclic aromatic compound of general formula (I): Ar 1 Ar 2 Ar 3 (I), while the α-diketone compound has a structure wherein a compound having a double bond is added in an eliminable state to a fused polycyclic aromatic compound. The fused polycyclic aromatic compound is dinaphthothienothiophene or the like, while the compound having a double bond is hexachlorocyclopentadiene or the like. In general formula (I), Ar 1 , Ar 2 and Ar 3 are each as defined in the description.