5-methyl-N-[(E)-(4-quinazolin-4-yloxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-methyl-N-[(E)-(4-quinazolin-4-yloxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide
• 化学式: C₂₀H₁₆N₆O₂
• 分子量: 372.4
• InChiKey: OIHAGOWWJMRFMM-FOKLQQMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• METHODS FOR CONTROLLING PROSTAGLANDIN-MEDIATED BIOLOGICAL PROCESSES
  申请人：Cornell University

  公开号：US20220160705A1

  公开（公告）日：2022-05-26

  Described herein are compositions and methods for reducing prostaglandin production and pain in a mammalian or avian subject. Such compositions and methods inhibit reduce prostaglandinendoperoxide synthase 2 (Ptgs2/Cox-2) and prostaglandin E synthase (Ptges/mPGES-1) activities in the subject, but do not substantially inhibit prostaglandin-endoperoxide synthase 1 (Cox1) or prostaglandin E synthase 2 activities in the subject.