2-Methyldodecan-4-one | 61548-99-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyldodecan-4-one
• CAS: 61548-99-0
• 化学式: C₁₃H₂₆O
• 分子量: 198.34
• InChiKey: KRYYERQBFNLFGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• AMMONIUM CARBOXYLATE COMPOUND, CRYSTALLINE FORM, AMORPHOUS FORM AND PREPARATION METHOD THEREOF
  申请人：WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.

  公开号：US20200055812A1

  公开（公告）日：2020-02-20

  The present disclosure belongs to the field of chemical synthesis, and in particular relates to an ammonium carboxylate compound, a crystalline form and an amorphous form, and a preparation method thereof. The present disclosure prepares the compound and the crystalline form I and its single crystal, amorphous form and crystalline form II thereof. The compound, the crystalline forms, the single crystal and the amorphous form can stably exist and exhibit good solid forms, suitable for medicine-making. Furthermore, these products possess high purity and less single impurity. Moreover, the preparation methods of the present disclosure are easy to implement due to the simple processes with mild reaction conditions, and could produce products of high yield and high purity without complex purification steps. Furthermore, the preparation methods may facilitate safety, environmental protection, and industrial production.

  本公开属于化学合成领域，特别涉及一种铵羧酸盐化合物，其结晶形式和无定形形式，以及其制备方法。本公开制备了该化合物及其结晶形式I及其单晶体、无定形形式和结晶形式II。该化合物、结晶形式、单晶体和无定形形式可以稳定存在，并展现出良好的固态形式，适用于药物制备。此外，这些产品具有高纯度和较少的单一杂质。此外，由于简单的过程和温和的反应条件，本公开的制备方法易于实施，并且可以在不复杂的纯化步骤下产生高产量和高纯度的产品。此外，这些制备方法可能有助于安全、环保和工业生产。
• Process to prepare eplerenone
  申请人：——

  公开号：US20030232981A1

  公开（公告）日：2003-12-18

  The present invention involves intermediates, including a 7&agr;-substituted steroid (II), 1 and processes which are used to prepare eplerenone, a useful pharmaceutical agent.

  本发明涉及中间体，包括一种7α-取代类固醇（II），以及用于制备依普利酮（eplerenone）这种有用的药物的工艺。
• Polymorphic forms of ramelteon and processes for preparation thereof
  申请人：Perlman Nurit

  公开号：US20090105490A1

  公开（公告）日：2009-04-23

  An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention.

  提供了一种无定形形态的拉莫三嗪，以及无定形和晶体拉莫三嗪的混合物。还提供了制备无定形拉莫三嗪和无定形和晶体拉莫三嗪混合物的方法，包括无定形拉莫三嗪和无定形和晶体拉莫三嗪混合物的制药组合物，以及使用本发明的组合物治疗失眠的方法。
• Purification of Mupirocin
  申请人：Bisschops Marc Antonius Theodorus

  公开号：US20080234503A1

  公开（公告）日：2008-09-25

  A method for purification of the antibiotic mupirocin (pseudomonic acid A) which comprises: a) Causing or allowing precipitation of mupirocin from an aqueous solution thereof; b) Recovering the precipitate; c) Dissolving the recovered precipitate in an organic solvent.

  一种纯化抗生素莫匹罗星（假单胞菌酸A）的方法，包括：a）使或允许莫匹罗星从其水溶液中沉淀；b）回收沉淀；c）将回收的沉淀在有机溶剂中溶解。
• [EN] PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING<br/>[FR] INHIBITEURS PYRIDILES DE SIGNALISATION HEDGEHOG
  申请人：GENENTECH INC

  公开号：WO2009126863A2

  公开（公告）日：2009-10-15

  The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.

  本发明提供了新型的刺猬信号抑制剂，可用作治疗恶性肿瘤的治疗剂，其中化合物具有一般式(I)：其中A、X、Y、R1、R2、R3、R4、m和n如本文所述。